4.6 Article

SARS-CoV-2-specific Cell-mediated Immunity in Kidney Transplant Recipients Recovered From COVID-19

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Virology

SARS-CoV-2-reactive interferon-γ-producing CD8+T cells in patients hospitalized with coronavirus disease 2019

Estela Gimenez et al.

Summary: In COVID-19 patients, a significant percentage of SARS-CoV-2-reactive IFN-gamma producing CD8+ T cells, independent of disease severity, were detected. Further studies are needed to determine if quantification of these T-cell subsets can provide prognostic information on the clinical course of COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

Article Surgery

T cell and antibody responses to SARS-CoV-2: Experience from a French transplantation and hemodialysis center during the COVID-19 pandemic

Sophie Candon et al.

Summary: The study found that transplant patients were able to mount strong T cell and antibody responses to the SARS-CoV-2 virus after reducing immunosuppressive therapy, aiding in differential diagnosis and potentially playing a role in the development of severe forms of the disease.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Article Surgery

COVID-19 in transplant recipients: The Spanish experience

Elisabeth Coll et al.

Summary: This study reported the experience of solid organ and hematopoietic stem cell transplant recipients diagnosed with COVID-19 in Spain until July 13, 2020. The incidence of COVID-19 in transplant recipients was higher than the general population. Most patients required hospitalization, and adjusting immunosuppression could improve survival rates. Risk factors for death included age, lung transplantation, and hospital-acquired COVID-19.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

Article Immunology

Outcomes of Renal Transplant Recipients With SARS-CoV-2 Infection in the Eye of the Storm: A Comparative Study With Waitlisted Patients

Ismail H. Mohamed et al.

Summary: The study compared symptomatic SARS-CoV-2 positive waitlisted and transplant patients in the UK, finding a higher incidence of COVID-19 in waitlisted patients but more severe disease and higher mortality in the transplant group. C-reactive protein levels at 48 hours were predictive of mortality in both groups, indicating the importance of shielding measures to protect vulnerable patients during the pandemic.

TRANSPLANTATION (2021)

Review Immunology

T-cell responses and therapies against SARS-CoV-2 infection

Salman M. Toor et al.

Summary: COVID-19 is potentially an immune-related disease, where T cells play a crucial role with both pro- and anti-functions. Understanding the role of T cells in immune responses is essential for better management of COVID-19.

IMMUNOLOGY (2021)

Article Immunology

COVID-19 in Solid Organ Transplantation: A Matched Retrospective Cohort Study and Evaluation of Immunosuppression Management

Marta Miarons et al.

Summary: This study investigated the epidemiological and clinical characteristics of solid organ transplant patients during the SARS-CoV-2 epidemic in Barcelona, Spain. The results showed a trend towards higher mortality in SOT recipients compared to controls, with a notable risk of drug-drug interactions.

TRANSPLANTATION (2021)

Article Medicine, Research & Experimental

Sustained cellular immune dysregulation in individuals recovering from SARS-CoV-2 infection

Jacob K. Files et al.

Summary: SARS-CoV-2 infection leads to a prolonged period of immune dysregulation, with increased activation and exhaustion markers in T cells and B cells in both hospitalized and nonhospitalized individuals. The changes in T cell activation/exhaustion positively correlate with age, and severely infected individuals exhibited higher expression of activation and exhaustion markers.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Review Immunology

COVID-19 Therapeutics for Solid Organ Transplant Recipients; 6 Months Into the Pandemic: Where Are We Now?

Robin K. Avery

Summary: Therapeutic interventions for solid organ transplant (SOT) recipients with COVID-19 have evolved over two main eras during the pandemic: early era and later era. Initially, drugs like hydroxychloroquine, lopinavir-ritonavir, and tocilizumab were widely used, but later remdesivir, dexamethasone, and convalescent plasma became more common along with a variety of investigational and repurposed agents.

TRANSPLANTATION (2021)

Review Immunology

COVID-19 and Solid Organ Transplantation: A Review Article

Yorg Azzi et al.

Summary: Solid organ transplantation has been significantly impacted by the coronavirus pandemic, with high mortality rates reported in recipients. The pandemic led to complexities in transplantation, including new questions regarding donor and recipient screening, and decisions on continuing transplantation based on clinical implications of COVID-19 infection. The clinical outcomes of COVID-19 in transplantation may vary depending on the type of transplanted organ and recipient comorbidities.

TRANSPLANTATION (2021)

Article Surgery

Use of tocilizumab in kidney transplant recipients with COVID-19

Maria J. Perez-Saez et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2020)

Article Biochemistry & Molecular Biology

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

Takuya Sekine et al.

Article Multidisciplinary Sciences

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Julian Braun et al.

NATURE (2020)

Review Medicine, General & Internal

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

Gregory A. Poland et al.

LANCET (2020)

Article Surgery

Monitoring of Immunoglobulin Levels Identifies Kidney Transplant Recipients at High Risk of Infection

M. Fernandez-Ruiz et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2012)

Article Virology

Human immunopathogenesis of severe acute respiratory syndrome (SARS)

Mark J. Cameron et al.

VIRUS RESEARCH (2008)