期刊
TRANSPLANT IMMUNOLOGY
卷 64, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.trim.2020.101353
关键词
Corneal transplantation; Graft rejection; Macrophage polarization
资金
- Science and Technology Planning Project of Guangdong Province [2017A020211005]
- President Funding of Nanfang Hospital [2019B023, 2019Z017]
Macrophages play a crucial role in corneal transplantation rejection, with different phenotypes impacting the rejection process through polarization; understanding the types and polarization mechanisms of macrophages is essential for developing new therapies.
Corneal transplantation rejection remains an urgent problem threatening the success rate of high-risk patients. Macrophages are involved in the rejection of corneal transplants. Macrophages have M1 and M2 phenotypes, classified according their response to external stimuli. Macrophage polarization, through which these distinct forms are activated, is not only involved in the occurrence and development of inflammation, tumors, and autoimmune and other diseases, but also participates in graft rejection. This study provides an overview of the types of macrophages and mechanisms of their polarization, and review current knowledge regarding their involvement in corneal transplantation and potential therapeutic applications. Consideration of the relationship between the direction of macrophage polarization and the determination of graft survival and how it can be modified, is important for the development of novel corneal anti-rejection therapies.
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