4.6 Article

Survival patterns among venous thromboembolism patients with hematologic malignancies in Alberta, Canada from 2003 to 2015

期刊

THROMBOSIS RESEARCH
卷 199, 期 -, 页码 59-66

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2020.12.021

关键词

Hematologic neoplasms; Pulmonary embolism; Survival rate; Venous thromboembolism; Venous thrombosis

资金

  1. Quality of Care and Effectiveness Research platform of the CIHR operating grant CanVECTOR (Canadian Venous Thromboembolism Clinical Trials and Outcomes Research) Network [CDT 142654]
  2. Marshall Eliuk Fund for Clinical Innovation in Hematology, University of Alberta [RES0039268]

向作者/读者索取更多资源

The study identified the prevalence of VTE in hematologic malignancy patients and compared survival outcomes with or without VTE. The results showed that VTE adversely affects survival among patients with hematologic malignancies, especially in those with specific conditions like MDS, MPN, and plasma cell dyscrasia.
Background: Hematologic malignancies are at increased risk of developing venous thromboembolism (VTE). Objectives: We aimed to identify the prevalence of hematologic malignancy in VTE patients and compare the survival with or without VTE. Methods: Using linked administrative data and a validated algorithm we identified VTE cases in Alberta, Canada from 2003 to 2015. Subjects having International Classification of Diseases code for hematologic malignancies, solid tumors and both cancers within 1 year before and after the VTE index event were defined as cancer associated VTE cases. We also identified patients with no VTE. Cox proportional hazards model was applied to estimate the hazard ratio (HR) of death. Kaplan Meier analysis was performed to compare survival rate between different groups. Results: We identified 5157 cancer associated VTE patients and 24,932 cancer patients with no VTE. Among the cancer associated VTE patients 697 (13.5%), 4376 (84.9%) and 84 (1.6%) had hematologic malignancies, solid tumors and both cancers, respectively. The median survival (in months) was significantly shorter in myelodysplastic syndrome (MDS), myeloproliferative neoplasm (MPN) and plasma cell dyscrasia patients with VTE than those without (16.6 vs 27.1, p = 0.004; 70.6 vs 99.2, p = 0.023 and 32.9 vs 55.5, p = 0.007 respectively). Occurrence of pulmonary embolism in MDS and MPN patients and deep vein thrombosis in plasma cell dyscrasia patients were significantly associated with increased risk of death (adjusted HR: 3.0, 95% CI: 1. 46?6.16; adjusted HR 1.60, 95% CI:1.01?2.51 and adjusted HR: 1.40, 95% CI: 1.03?1.89 respectively). Conclusions: VTE adversely affects the survival among patients with hematologic malignancies.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据