期刊
TETRAHEDRON LETTERS
卷 68, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2021.152945
关键词
Microansamycin; Total synthesis; Heck reaction; Horner-Wadsworth-Emmons olefination
资金
- Chulabhorn Graduate Institute
- Center of Excellence on Environmental Health and Toxicology
- Science & Technology Postgraduate Education and Research Development Office (PERDO)
- Ministry of Education
- Thailand Research Fund [MRG6280082]
This paper reports the first total synthesis of microansamycin I via a five-step chemical sequence, with an early-stage Heck reaction and Horner-Wadsworth-Emmons olefination as key steps.
Herein, we report the first total synthesis of microansamycin I via a five-step chemical sequence. Key to our reported synthesis is an early-stage Heck reaction, which enables convergent assembly of the dienone side chain via a Horner-Wadsworth-Emmons olefination. (C) 2021 Elsevier Ltd. All rights reserved.
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