Microwave-assisted synthesis of phenylpyrimidine derivatives via Suzuki-Miyaura reactions in water

An efficient method was developed to prepare biphenylpyrimidine scaffolds via a Suzuki-Miyaura coupling reaction. In this procedure, the products were synthesized under microwave irradiation in water and analogues of biguanidine were employed as ligands. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

An efficient method was developed to prepare biphenylpyrimidine scaffolds via a Suzuki-Miyaura coupling reaction under microwave irradiation in water, and biguanidine analogues were employed as ligands.