Copper-catalysed direct difluoromethylselenolation of aryl boronic acids with Se-(difluoromethyl) 4-methylbenzenesulfonoselenoate

In this study, we developed the first copper-catalysed direct difluoromethylselenolation of aryl boronic acids using Se-(difluoromethyl) 4-methylbenzenesulfonoselenoate as a difluoromethylselenolation reagent. Owing to the cheap and readily accessible reagents, broad substrate scope, and mild reaction conditions, this is an alternative and practical strategy for the synthesis of aryl difluoromethylselenylether. (C) 2021 Published by Elsevier Ltd.

Automated summary

In this study, a novel method for the synthesis of aryl difluoromethylselenylether was developed by copper-catalysed direct difluoromethylselenolation of aryl boronic acids. This method offers a broad substrate scope, utilizes cheap and readily accessible reagents, and operates under mild reaction conditions.