期刊
TALANTA
卷 224, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.talanta.2020.121845
关键词
Ionic liquid; AuPd nanoparticles; Molecularly imprinted polymer; Electrochemical sensor; Paracetamol
资金
- National Natural Science Foundation of China [21775112]
An innovative electrochemical sensor for paracetamol (PCM) determination was developed using a 3D AuPd nanoparticles-ionic liquid (IL) functionalized graphene-carbon nanotubes nanocomposite modified glassy carbon electrode. The sensor exhibited high sensitivity and selectivity, allowing for accurate detection of PCM in biological samples.
An innovative electrochemical sensor for paracetamol (PCM) determination was fabricated by electropolymerization imprinting on three-dimension (3D) AuPd nanoparticles-ionic liquid (IL) functionalized graphene-carbon nanotubes nanocomposite (AuPd/GN-CNTs-IL) modified glassy carbon electrode. The GN-CNTs supported AuPd alloy nanoparticles were prepared via one-pot hydrothermal method in the presence of IL (i.e. 1-hydroxyethyl-3-methyl imidazolium bis[(trifluoromethyl) sulfonyl] imide), which not only promoted the formation of small AuPd alloy nanoparticles, but also acted as spacer to prevent the 7C-7C stacking and aggregation of graphene sheets and carbon nanotubes. The resulting composite had large surface area and high electrocatalysis. The PCM imprinted poly(carbazole-co-pyrrole) exhibited good recognition to PCM and had high stability. Based on the synergic effect of PCM imprinted copolymer and 3D AuPd/GN-CNTs-IL nanocomposite, a highly selective and sensitive electrochemical sensor was established. It presented a good linear relationship from 0.10 to 10 mu M with a low limit of detection of 50 nM (S/N = 3). The sensor could be applied to the detection of PCM in biological samples, with acceptable recoveries (84.5%-102%). In addition, it was successfully used to monitor the concentration of PCM in urine from a patient with fever cold.
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