Total Mycosynthesis: Rational Bioconstruction and Bioengineering of Fungal Natural Products

Total biosynthesis in fungi is beginning to compete with traditional chemical total synthesis campaigns. Herein, the advantages, disadvantages and future opportunities are discussed within the scope of several recent examples. 1 Introduction 2 Synthetic Examples 2.1 2-Pyridones 2.2 Cytochalasans 2.3 Sorbicillinoids 2.4 Decalins: Solanapyrone 2.5 alpha-Pyrone Polyenes: Citreoviridin and Aurovertin 2.6 Anditomin and Related Meroterpenoids 2.7 Tropolone Sesquiterpenoids 3 Conclusion

Automated summary

This article discusses the advantages, disadvantages, and future opportunities of total biosynthesis in fungi, focusing on several recent examples such as 2-pyridones, cytochalasans, and sorbicillinoids.