Titanium: A Unique Metal for Radical Dehydroxylative Functionalization of Alcohols

The dehydroxylative functionalization of alcohols is synthetic appealing, but it remains a long-term challenge in the synthetic community. Low-valent titanium has shown the power to produce carbon radicals from alcohols via homolytic cleavage of the C-OH bonds and thus offers the potential to overcome this problem. In this perspective manuscript, we summarized the recent advance on radical dehydroxylative transformation of alcohols either promoted or catalyzed by titanium. The limitation and outlook of the studies in this field are also provided.

Automated summary

This perspective manuscript summarizes the recent advances in radical dehydroxylative transformation of alcohols either promoted or catalyzed by titanium, highlighting the potential of low-valent titanium in producing carbon radicals from alcohols. The limitations and future prospects in this field are also discussed.