期刊
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
卷 36, 期 1, 页码 314-320出版社
SPRINGER
DOI: 10.1007/s00464-020-08278-w
关键词
Abdominal symptoms; Colorectal cancer; Endoscopic submucosal dissection; Gastrointestinal symptom rating scale; Quality of life
类别
This study was a prospective multicenter observational trial aiming to investigate the impact of colorectal ESD on postoperative abdominal symptoms. The overall GSRS scores slightly improved after ESD, with statistically significant differences in indigestion syndrome and constipation syndrome, indicating that colorectal ESD is a minimally invasive treatment with no clinically significant differences in postoperative abdominal symptoms.Unicode is a registered trademark of Unicode, Inc. in the United States and other countries.
Background Endoscopic submucosal dissection (ESD) is an effective procedure to resect large superficial gastrointestinal neoplasms. In gastric ESD, several studies showed the relationship between postoperative abdominal symptoms and endoscopic treatment. However, the influence of colorectal ESD on abdominal symptoms after treatment is still unknown. To the best of our knowledge, this is the first prospective multicenter study performed to investigate the impact of colorectal ESD on postoperative abdominal symptoms. This study aimed to clarify the association between change of abdominal symptoms and ESD. Methods This study was a prospective multicenter observational trial that enrolled 141 out of 171 patients who underwent colorectal ESD and answered the Gastrointestinal Symptom Rating Scale (GSRS) questionnaire from March 2015 to August 2019. We evaluated abdominal symptoms in the patients using the GSRS questionnaire before ESD and a few weeks after ESD. Results Comparing the GSRS before and after ESD, overall scores changed from 1.58 +/- 0.58 to 1.48 +/- 0.48, and the five subscales (reflux syndrome, abdominal pain, indigestion syndrome, diarrhea syndrome, and constipation syndrome) were slightly improved. Overall scores, indigestion syndrome, and constipation syndrome were statistically significantly different before and after ESD (P < 0.05). Conclusions In GSRS, a score of >= 3 is often treated as a clinically significant symptom. Therefore, our findings indicated that there was no clinically significant difference. For this reason, colorectal ESD does not affect postoperative abdominal symptoms and is considered a minimally invasive treatment. The analysis of the impact of colon ESD on gastrointestinal symptoms UMIN000016914.
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