For Whom the Bell Tolls: The Structure of the Dead Kinase, IRAK3

In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.

Automated summary

In this study, the structure of the pseudokinase domain of IRAK3 was reported, revealing a head-to-head dimer formation and a potential mode of regulation for attenuating IRAK4 activity.