4.7 Editorial Material

For Whom the Bell Tolls: The Structure of the Dead Kinase, IRAK3

期刊

STRUCTURE
卷 29, 期 3, 页码 197-199

出版社

CELL PRESS
DOI: 10.1016/j.str.2021.01.011

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资金

  1. National Health and Medical Research Council of Australia (NHMRC) [1172929]
  2. NHMRC IRIISS [9000653]
  3. Victorian State Government Operational Infrastructure Support Scheme
  4. National Health and Medical Research Council of Australia [9000653] Funding Source: NHMRC

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In this study, the structure of the pseudokinase domain of IRAK3 was reported, revealing a head-to-head dimer formation and a potential mode of regulation for attenuating IRAK4 activity.
In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.

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