New Avenues for Optimal Treatment of Atrial Fibrillation and Stroke Prevention

One in 3 individuals free of atrial fibrillation (AF) at index age 55 years is estimated to develop AF later in life. AF increases not only the risk of ischemic stroke but also of dementia, even in stroke-free patients. In this review, we address recent advances in the heart-brain interaction with focus on AF. Issues discussed are (1) the timing of direct oral anticoagulants start following an ischemic stroke; (2) the comparison of direct oral anticoagulants versus vitamin K antagonists in early secondary stroke prevention; (3) harms of bridging with heparin before direct oral anticoagulants; (4) importance of appropriate direct oral anticoagulants dosing; (5) screening for AF in high-risk populations, including the role of wearables; (6) left atrial appendage occlusion as an alternative to oral anticoagulation; (7) the role of early rhythm-control therapy; (8) effect of lifestyle interventions on AF; (9) AF as a risk factor for dementia. An interdisciplinary approach seems appropriate to address the complex challenges posed by AF.

Automated summary

Atrial fibrillation (AF) increases the risk of ischemic stroke and dementia, necessitating a comprehensive interdisciplinary approach to address the complex challenges it poses. Considerations include timing of anticoagulant therapy post-stroke, comparison of different types of anticoagulants, harms of bridging therapy, appropriate dosing, AF screening, left atrial appendage occlusion, rhythm-control therapy, lifestyle interventions, and the relationship between AF and dementia.