期刊
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
卷 249, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2020.119328
关键词
Leucine aminopeptidase; Liver cancer; Quinoline; Ratiometric; Hepatoma-specific
类别
资金
- Start up fund for doctoral research of Shaoxing University [20185020]
- Zhejiang public welfare fund project [LGG19B02002]
In this study, a novel fluorescent probe Gal-QL-Leu was developed based on the quinoline group for monitoring LAP activity in liver tumor cells. The probe demonstrated ratiometric characteristics, high selectivity, good biocompatibility, and high sensitivity, showing great potential for detecting LAP activity in liver tumor cells.
Leucine aminopeptidase (LAP) is known as an important potential biomarker for liver malignancy and it is urgent to develop an intuitive and effective method to monitor the activity of LAP in liver cancer. Although, numerous LAP fluorescent probes had been developed, it is still a challenge to detect LAP activity in liver cancer. Herein, combained with the DFT, we reported a novel galactose-appended hepatoma-specific ratiometric fluorescent probe (Gal-QL-Leu) based on quinoline group for imaging and tracing LAP in liver tumor cells. Probe Gal-QL-Leu demonstrated a obvious ratiometric characteristics, better selectivity, good biocompatibility and high sensitivity. Moreover, the selective imaging of LAP in HepG2, HCT116, A549 and HeLa cells had been achieved with probe Gal-QL-Leu, demonstrating good application prospect in the detection of LAP activity in liver tumor cells. (C) 2020 Published by Elsevier B.V.
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