A pyridine-Si-rhodamine-based near-infrared fluorescent probe for visualizing reactive oxygen species in living cells

A lysosomal-targeted near infrared (NIR) fluorescent probe for reactive oxygen species (ROS) was developed with highly sensitive ability. The different responding activity toward H2O2, center dot OH, and HClO were investigated. Meanwhile, the probe has been successfully applied in detecting and imaging reactive oxygen species both in cells and in vivo. (c) 2020 Elsevier B.V. All rights reserved.

Automated summary

A lysosomal-targeted near infrared fluorescent probe with high sensitivity towards reactive oxygen species (ROS) was developed, showing different response activity towards H2O2, · OH, and HClO. It has been successfully used for ROS detection and imaging in cells and in vivo.