期刊
SMALL
卷 17, 期 14, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202006612
关键词
flexible electronics; liquid metal; neural interfacing; stretchable neural electrode arrays
类别
资金
- National Key R&D Program of China [2018YFA0902600, 2017YFA0205901]
- National Natural Science Foundation of China [81730051, 21761142006, 21535001, 32071035, 31871080]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026, XDA16020902]
- Shenzhen Bay Laboratory [SZBL2019062801004]
- Guangdong Innovative and Entrepreneurial Research Team Program [2019ZT08Y191]
- Guangdong Natural Science Fund for Distinguished Young Scholars [2020B1515020042]
- Special Support Project for Outstanding Young Scholars of Guangdong Province [2019TQ05Y177]
- Tencent Foundation through the XPLORER PRIZE
A new fabrication strategy for highly stretchable neural electrode arrays based on screen printing of liquid metal conductors onto polydimethylsiloxane substrates was developed. The electrode arrays show a resolution of 50 μm and high biocompatibility, retaining stable electrical properties and mechanical performance under significant strain.
The adoption of neural interfacing into neurological diagnosis is severely hampered by the complex, costly, and error-prone manufacturing methods, requiring new fabrication processes and materials for flexible neural interfacing. Here a strategy for fabricating highly stretchable neural electrode arrays based on screen printing of liquid metal conductors onto polydimethylsiloxane substrates is presented. The screen-printed electrode arrays show a resolution of 50 mu m, which is ideally applicable to neural interfaces. The integration of liquid metal-polymer conductor enables the neural electrode arrays to retain stable electrical properties and compliant mechanical performance under a significant (approximate to 108%) strain. Taking advantage of its high biocompatibility, liquid metal electrode arrays exhibit excellent performance for neurite growth and long-term implantation. The stretchable electrode arrays can spontaneously conformally come in touch with the brain surface, and high-throughput electrocorticogram signals are recorded. Based on stretchable electrode arrays, real-time monitoring of epileptiform activities can be provided at different states of seizure. The method reported here offers a new fabrication strategy to manufacture stretchable neural electrodes, with additional potential utility in diagnostic brain-machine interfaces.
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