期刊
SMALL
卷 17, 期 13, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202007551
关键词
human neutrophil elastase (HNE); peptide immobilization; polymeric matrix; solution electrospinning
类别
资金
- European Research Council (ERC) [617989]
- German Research Foundation (DFG) [INST 105022/58-1 FUGG, TRR225, 326998133-TRR 225]
- Projekt DEAL
Biointerface engineering is a strategy to enhance the healing and tissue integration of biomaterials, with integrating specific peptides being a promising approach. Neutrophils, as the first immune cells recruited to implant sites, play an important role in the interaction with bioactivated materials. A sacrificial transient hydrogel coating has been introduced to protect peptide-modified surfaces from immediate cleavage by neutrophil elastase.
Biointerface engineering is a wide-spread strategy to improve the healing process and subsequent tissue integration of biomaterials. Especially the integration of specific peptides is one promising strategy to promote the regenerative capacity of implants and 3D scaffolds. In vivo, these tailored interfaces are, however, first confronted with the innate immune response. Neutrophils are cells with pronounced proteolytic potential and the first recruited immune cells at the implant site; nonetheless, they have so far been underappreciated in the design of biomaterial interfaces. Herein, an in vitro approach is introduced to model and analyze the neutrophil interaction with bioactivated materials at the example of nano-bioinspired electrospun surfaces that reveals the vulnerability of a given biointerface design to the contact with neutrophils. A sacrificial, transient hydrogel coating that demonstrates optimal protection for peptide-modified surfaces and thus alleviates the immediate cleavage by neutrophil elastase is further introduced.
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