Rapid recovery of At-211 by extraction chromatography

The near quantitative separation, purification, and recovery of At-211 has been demonstrated through an extraction chromatography process which utilizes porous beads impregnated with 3-octanone, resulting in an elution yield of 92-95%. Moreover, the rapid nature of this process, <20 min, was achieved after dissolution of a Bi metal target in HNO3 following retrieval from the beamline after alpha-particle bombardment. The solution was directly loaded onto the column with no volume or acidity adjustment. The column was washed with HNO3 and H2O, and At-211 was eluted with ethanol, collecting roughly 87-93% in 1 mL. This process of recovering high purity At-211, in near quantitative yields, represents a significant advance in At separations.

Automated summary

The near quantitative separation, purification, and recovery of At-211 has been demonstrated through a rapid extraction chromatography process, achieving elution yields of 92-95%. This represents a significant advance in At separations, with high purity At-211 recovered in near quantitative yields.