期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 331, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2021.129439
关键词
Bismuth (Bi3+); Fluorescence; Terbium; Probe; Plasma; Urine; Bismuth drug
资金
- National Natural Science Foundation of China (NSFC) [21575023]
- Natural Science Foundation of Jiangsu Province [BK20161414]
- Key Research and Development Plan of Jiangsu Province [BE2019715]
A novel and ultra-sensitive probe for Bi3+ ions based on terbium chelate fluorescence was developed, with a detection limit of 0.1 pM in aqueous solution and 1 pM in urine and plasma. The probe shows high sensitivity and can be used for trace Bi3+ detection in medicine, urine, and plasma samples. Additionally, the probe's long fluorescence lifetime allows for efficient elimination of nonspecific fluorescence, making it advantageous for biological sample analysis.
A novel, ultrasensitive probe of Bi3+ ion based on the fluorescence of a terbium chelate was presented and synthesized. This terbium chelate probe for Bi3+ is composed of a carbostyril-linked polyaminocarboxylate chelator and fluorescent terbium ion, and is highly fluorescent due to the sensitization of carbostyril to terbium ion. The extremely strong binding of polyaminocarboxylate chelator to Bi3+ replaced the binding of terbium ion, quenching the fluorescence of the probe. The probe based on this principle shows an ultra-high sensitivity for the detection of Bi(3+ )with a limit of detection as low as 0.1 pM in aqueous solution and 1 pM in urine and plasma solution respectively, at least 100-fold more sensitive than current various assays for Bi3+. The probe can be used to determine trace Bi3+ in medicines, urine and plasma. Due to a long fluorescence lifetime of the probe containing terbium ion, which allows the elimination of various short-lived nonspecific fluorescence via a time-delay measurement, this probe is particularly advantageous for the determination of biological samples like plasma and urine with autofluorescence.
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