期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 329, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.129259
关键词
Photothermal biosensor; Diabetes; Sialic acid; Temperature detector; Microfluidic
资金
- National Research Foundation of Korea(NRF) - Korea government(MSIT) [2020R1A5A1018052, 2018R1C1B6002499, 2018R1A2A2A15019814]
- Korea Environment Industry & Technology Institute(KEITI) through Aquatic Ecosystem Conversion Research Program - Korea Ministry of Environment(MOE) [2020003030007]
- National Research Foundation of Korea [2020R1A5A1018052, 2018R1A2A2A15019814, 2018R1C1B6002499] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Photothermal sensors are a novel type of probe with potential in clinical diagnostics, and a micro-NiRTD has been developed for selective monitoring of diabetes with improved cost efficiency and sensitivity. The micro-NiRTD shows a significant enhancement in discriminatory ability for diabetic clinical samples compared to previous designs, making it a convenient, rapid, reliable, and cost-effective biosensor for monitoring diabetes patients.
Photothermal sensors represent a novel type of probe having potential in the field of clinical diagnostics particularly due to the lack of a tedious sample pre-treatment, a sophisticated equipment and a skilled manpower. Herein, we describe the fabrication of a micmfluidic nickel-resistive temperature detector (micro-NiRTD) for the selective monitoring of diabetes using a boronate-based sialic acid (SA) receptor. This work represents an improvement made to our previous photothermal sensor designs by reducing the cost by about 100-fold and significantly improving the sensitivity of the device, enabling the detection of sialic acid contents as low as 0.06 mu mol/mL, a 4-fold improvement compared to the sensor described our previous study. The average temperature difference between healthy subjects and diabetes patients was found to be 0.181 degrees C dL/g with micro-Ni-RTD in comparison with 0.043 degrees C dL/g with our previous platinum-based resistive temperature detector (Pt-RTD) reported previously The enhancement in the discriminatory ability of micro-Ni-RTD for the diabetic clinical samples compared with healthy control can be attributed to the modified surface modification strategy and the incorporation of the micmfluidic channels. Thus, micro-Ni-RTD represents a convenient, rapid, reliable, and low-cost biosensor for the clinical monitoring of diabetes patients.
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