相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs
Vural Tagal et al.
CANCER RESEARCH (2021)
Centrosome loss results in an unstable genome and malignant prostate tumors
Mengdie Wang et al.
ONCOGENE (2020)
Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity
Yurena Vivas-Garcia et al.
MOLECULAR CELL (2020)
Polyploidy in Cardiomyocytes Roadblock to Heart Regeneration?
Wouter Derks et al.
CIRCULATION RESEARCH (2020)
Olaparib in patients with metastatic castration-resistant prostate cancer with DNA repair gene aberrations (TOPARP-B): a multicentre, open-label, randomised, phase 2 trial
Joaquin Mateo et al.
LANCET ONCOLOGY (2020)
STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations
James Kim et al.
CANCERS (2020)
Persistent DNA damage triggers activation of the integrated stress response to promote cell survival under nutrient restriction
Elena Clementi et al.
BMC BIOLOGY (2020)
Transcriptional downregulation of MHC class I and melanoma de- differentiation in resistance to PD-1 inhibition
Jenny H. Lee et al.
NATURE COMMUNICATIONS (2020)
Polyploidy in liver development, homeostasis and disease
Romain Donne et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)
ATM-associated signalling triggers the unfolded protein response and cell death in response to stress
Yuka Hotokezaka et al.
COMMUNICATIONS BIOLOGY (2020)
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma
Catherine S. Grasso et al.
CANCER CELL (2020)
The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis
Xiaomeng Zhang et al.
ONCOGENE (2020)
The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression
Christina Jessen et al.
ONCOGENE (2020)
Vimentin filaments drive migratory persistence in polyploidal cancer cells
Botai Xuan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes
Rolando Ruiz-Vega et al.
ELIFE (2020)
PARP Inhibitors: Clinical Relevance, Mechanisms of Action and Tumor Resistance
Maddison Rose et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis
Valentina C. Sladky et al.
EMBO REPORTS (2020)
Activation of S6 signaling is associated with cell survival and multinucleation in hyperplastic skin after epidermal loss of AURORA-A Kinase
Weston Kenneth Ryan et al.
CELL DEATH AND DIFFERENTIATION (2019)
Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells
Or-Yam Revach et al.
CANCER RESEARCH (2019)
Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients
Mirjam Fassler et al.
JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)
Senescent cell clearance by the immune system: Emerging therapeutic opportunities
Larissa G.P. Langhi Prata et al.
SEMINARS IN IMMUNOLOGY (2019)
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma
Yochai Wolf et al.
CELL (2019)
Melanoma plasticity and phenotypic diversity: therapeutic barriers and opportunities
Florian Rambow et al.
GENES & DEVELOPMENT (2019)
Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
J. Larkin et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
Hyunchul Jung et al.
NATURE COMMUNICATIONS (2019)
BRAF V600 Mutational Status in Melanoma Correlates with Cytologic Features in Fine-Needle Aspirate Specimens
Paul J. Lee et al.
ACTA CYTOLOGICA (2019)
The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas
Silke Appenzeller et al.
CANCER (2019)
A Review of Immune-Mediated Adverse Events in Melanoma
Lucy Boyce Kennedy et al.
ONCOLOGY AND THERAPY (2019)
Cytologic Features of Malignant Melanoma with Osteoclast-Like Giant Cells
Jose A. Jimenez-Heffernan et al.
ACTA CYTOLOGICA (2018)
Plexiform Atypical Spitz Tumor With Rosette-Like Giant Cells: A Histologic and Immunohistochemical Study on a Case Suggesting Ganglioneuroblastic Differentiation: Review of the Literature and Considerations on Histogenesis
Elena Castelli et al.
AMERICAN JOURNAL OF DERMATOPATHOLOGY (2018)
Cutaneous Melanocytoma With CRTC1-TRIM11 Fusion Report of 5 Cases Resembling Clear Cell Sarcoma
Lucie Cellier et al.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2018)
Multi-stage Differentiation Defines Melanoma Subtypes with Differential Vulnerability to Drug-Induced Iron-Dependent Oxidative Stress
Jennifer Tsoi et al.
CANCER CELL (2018)
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
Yong Yu et al.
CANCER CELL (2018)
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control
Jan P. Boettcher et al.
CELL (2018)
Toward Minimal Residual Disease-Directed Therapy in Melanoma
Florian Rambow et al.
CELL (2018)
RNA-seq analysis identifies different transcriptomic types and developmental trajectories of primary melanomas
Manfred Kunz et al.
ONCOGENE (2018)
Clinical characteristics and preliminary morphological observation of 47 cases of primary anorectal malignant melanomas
Guang Liu et al.
MELANOMA RESEARCH (2018)
Genomic instability in mutant p53 cancer cells upon entotic engulfment
Hannah L. Mackay et al.
NATURE COMMUNICATIONS (2018)
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade
Livnat Jerby-Arnon et al.
CELL (2018)
Polyamine metabolism and cancer: treatments, challenges and opportunities
Robert A. Casero et al.
NATURE REVIEWS CANCER (2018)
Interferon gamma, an important marker of response to immune checkpoint blockade in non-small cell lung cancer and melanoma patients
Niki Karachaliou et al.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)
Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma
Paola Falletta et al.
GENES & DEVELOPMENT (2017)
Dedifferentiation into blastomere-like cancer stem cells via formation of polyploid giant cancer cells
N. Niu et al.
ONCOGENE (2017)
The AP-1 transcription factor FOSL1 causes melanocyte reprogramming and transformation
K. Maurus et al.
ONCOGENE (2017)
Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
Teresa Davoli et al.
SCIENCE (2017)
Intratumor and Intertumor Heterogeneity in Melanoma
Tomasz M. Grzywa et al.
TRANSLATIONAL ONCOLOGY (2017)
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
Antje Sucker et al.
NATURE COMMUNICATIONS (2017)
Resistance to checkpoint blockade therapy through inactivation of antigen presentation
Moshe Sade-Feldman et al.
NATURE COMMUNICATIONS (2017)
MDM2 Antagonists Counteract Drug-Induced DNA Damage
Anna E. Vilgelm et al.
EBIOMEDICINE (2017)
MITF-High and MITF-Low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra- and Intertumoral Heterogeneity of Primary Melanoma
Marie Ennen et al.
CLINICAL CANCER RESEARCH (2017)
Crosstalk signaling in targeted melanoma therapy
Svenja Meierjohann
CANCER AND METASTASIS REVIEWS (2017)
Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method
Ruifang Mi et al.
ONCOLOGY REPORTS (2016)
The urgent need to recover MHC class I in cancers for effective immunotherapy
Federico Garrido et al.
CURRENT OPINION IN IMMUNOLOGY (2016)
The integrated stress response
Karolina Pakos-Zebrucka et al.
EMBO REPORTS (2016)
Intratumoral multinucleated giant cells are not a prognostic pathologic feature in cutaneous melanoma
Chutika Srisuttiyakorn et al.
JOURNAL OF CUTANEOUS PATHOLOGY (2016)
Harnessing the integrated stress response for the treatment of multiple sclerosis
Sharon W. Way et al.
LANCET NEUROLOGY (2016)
The transcription factor TBX2 regulates melanogenesis in melanocytes by repressing Oca2
Yu Chen et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2016)
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Itay Tirosh et al.
SCIENCE (2016)
Metastatic Disease in Polyploid Uveal Melanoma Patients Is Associated With BAP1 Mutations
Serdar Yavuzyigitoglu et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)
Genomic Classification of Cutaneous Melanoma
Rehan Akbani et al.
CELL (2015)
The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer
Fei Fei et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2015)
Outcome of patients with de novo versus nevus-associated melanoma
William M. Lin et al.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2015)
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Gina M. DeNicola et al.
NATURE GENETICS (2015)
Correction: Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma
Timothy A. Chan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
The Genetic Evolution of Melanoma from Precursor Lesions
A. Hunter Shain et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
Eliezer M. Van Allen et al.
SCIENCE (2015)
MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment
Stefanie Riesenberg et al.
NATURE COMMUNICATIONS (2015)
A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype
Verena Rohnalter et al.
ONCOTARGET (2015)
Mitotic Stress Is an Integral Part of the Oncogene-Induced Senescence Program that Promotes Multinucleation and Cell Cycle Arrest
Dina Dikovskaya et al.
CELL REPORTS (2015)
A Rare Case of Melanoma With Touton-like Giant Cells: A Potential Diagnostic Pitfall
Yen Tun Wang et al.
AMERICAN JOURNAL OF DERMATOPATHOLOGY (2014)
Cystathionase mediates senescence evasion in melanocytes and melanoma cells
C. Leikam et al.
ONCOGENE (2014)
Generation of cancer stem-like cells through the formation of polyploid giant cancer cells
S. Zhang et al.
ONCOGENE (2014)
Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma
Georgina V. Long et al.
NATURE COMMUNICATIONS (2014)
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
Judith Mueller et al.
NATURE COMMUNICATIONS (2014)
Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
Hubing Shi et al.
CANCER DISCOVERY (2014)
MAP Kinase Pathway Alterations in BRAF-Mutant Melanoma Patients with Acquired Resistance to Combined RAF/MEK Inhibition
Nikhil Wagle et al.
CANCER DISCOVERY (2014)
The MAPK pathway as an apoptosis enhancer in melanoma
Johannes M. Haydn et al.
ONCOTARGET (2014)
Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal
Jekaterina Erenpreisa et al.
CANCER CELL INTERNATIONAL (2013)
Identification of an Aurora Kinase Inhibitor Specific for the Aurora B Isoform
Hua Xie et al.
CANCER RESEARCH (2013)
Molecular Pathways: Induction of Polyploidy as a Novel Differentiation Therapy for Leukemia
Diane S. Krause et al.
CLINICAL CANCER RESEARCH (2013)
Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-?B impairs this drug-induced senescence
Yan Liu et al.
EMBO MOLECULAR MEDICINE (2013)
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Michael S. Lawrence et al.
NATURE (2013)
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov et al.
NATURE (2013)
Pan-cancer patterns of somatic copy number alteration
Travis I. Zack et al.
NATURE GENETICS (2013)
Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype
Mickal Ohanna et al.
ONCOTARGET (2013)
Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence
Katherine M. Aird et al.
CELL REPORTS (2013)
Stress-Regulated Transcription Factor ATF4 Promotes Neoplastic Transformation by Suppressing Expression of the INK4a/ARF Cell Senescence Factors
Michiko Horiguchi et al.
CANCER RESEARCH (2012)
Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation
Jennifer Landsberg et al.
NATURE (2012)
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
Anirudh Prahallad et al.
NATURE (2012)
Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations
Keith T. Flaherty et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11
J. E. Noll et al.
ONCOGENE (2012)
Two Cases of Multiple Spitz Nevi Correlating Clinical, Histologic, and Fluorescence In Situ Hybridization Findings
Susan L. Boone et al.
ARCHIVES OF DERMATOLOGY (2011)
Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation
Jekaterina Erenpreisa et al.
CELL BIOLOGY INTERNATIONAL (2011)
Senescent cells develop a PARP-1 and nuclear factor-κB-associated secretome (PNAS)
Mickael Ohanna et al.
GENES & DEVELOPMENT (2011)
Human Cutaneous Melanomas Lacking MITF and Melanocyte Differentiation Antigens Express a Functional Axl Receptor Kinase
Marialuisa Sensi et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2011)
Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
T. Strub et al.
ONCOGENE (2011)
Mitf is the key molecular switch between mouse or human melanoma initiating cells and their differentiated progeny
Y. Cheli et al.
ONCOGENE (2011)
Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
Jessie Villanueva et al.
CANCER CELL (2010)
The Spitz Nevus: Review and Update
Valerie B. Lyon
CLINICS IN PLASTIC SURGERY (2010)
Up-regulation of the embryonic self-renewal network through reversible polyploidy in irradiated p53-mutant tumour cells
Kristine Salmina et al.
EXPERIMENTAL CELL RESEARCH (2010)
Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465
Christine Pirker et al.
EXPERIMENTAL DERMATOLOGY (2010)
Melanomas acquire resistance toB-RAF(V600E) inhibition by RTK or N-RAS upregulation
Ramin Nazarian et al.
NATURE (2010)
The relative contributions of the p53 and pRb pathways in oncogene induced melanocyte senescence
Sebastian Haferkamp et al.
AGING-US (2009)
Senescence-Associated Oxidative DNA Damage Promotes the Generation of Neoplastic Cells
Karo Gosselin et al.
CANCER RESEARCH (2009)
Genetic stability of senescence reverted cells - Genome reduction division of polyploidy cells, aneuploidy and neoplasia
Kirsten H. Walen
CELL CYCLE (2008)
Death through a tragedy: mitotic catastrophe
H. Vakifahmetoglu et al.
CELL DEATH AND DIFFERENTIATION (2008)
Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence
C. Leikam et al.
ONCOGENE (2008)
Ectopic Tbx2 expression results in polyploidy and cisplatin resistance
E. Davis et al.
ONCOGENE (2008)
Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress
Demetrius M. Kokkinakis et al.
MOLECULAR CANCER RESEARCH (2006)
A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters
S Saxonov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
MITF: master regulator of melanocyte development and melanoma oncogene
Carmit Levy et al.
TRENDS IN MOLECULAR MEDICINE (2006)
BRAFE600-associated senescence-like cell cycle arrest of human naevi
C Michaloglou et al.
NATURE (2005)
Monster cells in malignant melanoma
AS Boyd et al.
AMERICAN JOURNAL OF DERMATOPATHOLOGY (2005)
BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
EE Patton et al.
CURRENT BIOLOGY (2005)
Cell death by mitotic catastrophe: a molecular definition
M Castedo et al.
ONCOGENE (2004)
Tbx2 directly represses the expression of the p21WAF1 cyclin-dependent kinase inhibitor
S Prince et al.
CANCER RESEARCH (2004)
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
JY Du et al.
CANCER CELL (2004)
Melanocytes and the Microphthalmia transcription factor network
E Steingrimsson et al.
ANNUAL REVIEW OF GENETICS (2004)
Transcriptional control of the arginine/lysine transporter, Cat-1, by physiological stress
J Fernandez et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cutaneous melanomas associated with nevi
C Bevona et al.
ARCHIVES OF DERMATOLOGY (2003)
Morphological changes and apoptosis in radial growth phase melanoma cell lines following ultraviolet-B irradiation
MR Hussein et al.
AMERICAN JOURNAL OF DERMATOPATHOLOGY (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding et al.
MOLECULAR CELL (2003)
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein - Implication for heme oxygenase-1 gene regulation
CH He et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of human breast cancers
JJL Jacobs et al.
NATURE GENETICS (2000)
Coordinate modulation of Sp1, NF-kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation
CR Yang et al.
FASEB JOURNAL (2000)
Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage
TM Illidge et al.
CELL BIOLOGY INTERNATIONAL (2000)
Release of mitotic descendants by giant cells from irradiated Burkitt's lymphoma cell lines
JA Erenpreisa et al.
CELL BIOLOGY INTERNATIONAL (2000)