4.3 Review

Personality changes in patients with refractory epilepsy after surgical treatment: A systematic review

期刊

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
卷 85, 期 -, 页码 95-101

出版社

W B SAUNDERS CO LTD
DOI: 10.1016/j.seizure.2020.12.026

关键词

Refractory epilepsy; Epilepsy surgery; Personality traits

资金

  1. Fondo de investigaciones sanitarias (FIS), Spain Government [PI080111]

向作者/读者索取更多资源

Most of the studies found adaptive personality changes in adult patients with drug-resistant epilepsy after surgical treatment, such as decreased neuroticism and impulsivity, while one study showed increased emotional lability. The extent of personality changes depended on the epileptogenic area, seizure status after treatment, and duration of follow-up.
Purpose: We aimed to conduct a systematic review to evaluate the personality changes in adult patients with drug-resistant epilepsy following surgical treatment. Methods: A systematic review was conducted using the Preferred Reporting Items of Systematic Reviews and MetaAnalyses (PRISMA) statement. We searched PubMed, Medline databases, and the Cochrane Controlled Trials Register, with search terms 'personality', 'epilepsy', and 'surgery'. Results: Eleven studies were selected. In 7 out of 11 studies, personality changes were more adaptive, with patients experiencing decreased neuroticism, impulsivity, hypochondriasis, psychasthenia. One study showed increased emotional lability. The remainder of the studies showed no changes in personality dimensions. Changes in personality differed according to the localization of the epileptogenic area, depended on seizure status after treatment and duration of follow-up. Seizure freedom as an outcome of surgical treatment influenced the existence of personality changes, and their severity. Adaptive personality changes could be seen from early follow-up assessments even in patients who were not seizure-free, though further follow-ups showed that improvements after 1-2 years were specific to seizure-free patients. Limitations: The main limitation of our research is the heterogeneity of approaches used to evaluate personality in the included studies. Furthermore, the included studies also had different sample sizes and comparison groups, different designs, and different follow-up durations. We only included studies that were written in English. Conclusions: The majority of studies reported changes in personality dimensions in patients suffering from refractory epilepsy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据