期刊
SCIENTOMETRICS
卷 126, 期 4, 页码 3513-3534出版社
SPRINGER
DOI: 10.1007/s11192-021-03871-9
关键词
Correction; Experimental reagent; Expression of concern; Gene knockdown; Nucleotide sequence; Retraction
资金
- US Office of Research Integrity [ORIIR180038-01-00]
- National Health and Medical Research Council of Australia [APP1184263]
This study compared journal responses to a specific reagent error in 31 human gene knockdown publications, revealing variations in responses between journals and suggesting a need for editorial staff to have more support in interpreting post-publication notifications of incorrect nucleotide sequences. A draft template was proposed to facilitate communication, interpretation, and investigation of published errors, including those affecting research reagents.
The capacity of the scientific literature to self-correct is of vital importance, but few studies have compared post-publication journal responses to specific error types. We have compared journal responses to a specific reagent error in 31 human gene knockdown publications, namely a non-targeting or negative control nucleotide sequence that is instead predicted to target a human gene. The 31 papers published by 13 biomedical journals generated 26 published responses (14 retractions, 5 expressions of concern, 7 author corrections which included one resolved expression of concern) as well as 6 stated decisions to take no action. Variations in published responses were noted both between journals and by 4 journals that published different responses to at least 2 papers. A subset of published responses revealed conflicting explanations for the wrongly identified control reagent, despite 30/31 papers obtaining their gene knockdown reagents from the same external supplier. Viewed collectively, different journal responses to human gene knockdown publications with a common reagent error type suggest that editorial staff require more support to interpret post-publication notifications of incorrect nucleotide sequence reagents. We propose a draft template to facilitate the communication, interpretation and investigation of published errors, including errors affecting research reagents.
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