期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 756, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2020.143922
关键词
Neurotoxicity; Behavior; Ecotoxicology; Pollution; Lab-on-a-Chip; Microfluidics; Animal tracking; Video
Neurotoxicity effects of industrial contaminants are currently not well studied, with behavioral changes in small aquatic invertebrates being proposed as useful indicators, but limited by lack of advancements in analytical technologies. Advances in Lab-on-a-Chip technologies show promise in addressing these limitations and facilitating high-throughput neuro-behavioral ecotoxicity testing.
Neurotoxicity effects of industrial contaminants are currently significantly under investigated and require innovative analytical approaches to assess health and environmental risks at individual, population and ecosystem levels. Behavioral changes assessed using small aquatic invertebrates as standard biological indicators of the aggregate toxic effects, have been broadly postulated as highly integrative indicators of neurotoxicity with physiological and ecological relevance. Despite recent increase in understanding of the emerging value of behavioral biotests, their wider implementation especially in high-throughput environmental risk assessment assays, is largely limited by the lack of advances in analytical technologies. To date, most of the behavioral biotests have only been performed with larger-volumes and lacked dynamic flow-through conditions. They also lack features necessary for development of higher throughput neuro-behavioral ecotoxicity assays such as miniaturization and integration of automated components. We postulate that some contemporary analytical limitations can be effectively addressed by innovative Lab-on-a-Chip (LOC) technologies, an emerging and multidisciplinary field poised to bring significant miniaturization to aquatic ecotoxicity testing. Recent developments in this emerging field demonstrate particular opportunities to study a plethora of behavioral responses of small model organisms in a high-throughput fashion. In this review, we highlight recent advances in this budding new interdisciplinary field of research. We also outline the existing challenges, barriers to development and provide a future out-look in the evolving field of neurobehavioral ecotoxicology. (C) 2020 Elsevier B.V. All rights reserved.
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