期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 757, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2020.143967
关键词
Psoriasis; Vitiligo; Cadmium; Lead; Mercury; Dietary habits
资金
- Ministry of Science and Higher Education [154-31549F, POPW.01.03.00-20-022/09]
The study aimed to assess the influence of dietary habits on the concentration of Cd, Pb and Hg in patients with psoriasis and vitiligo. Elevated levels of these toxic elements could increase oxidative stress and contribute to inflammation in the pathogenesis of skin disorders. Food habits have impact on the content of examined toxic metals in the blood of patients, which may be useful for composing the diet and prevention of psoriasis and vitiligo.
Background: Psoriasis and vitiligo are common, autoimmune skin diseases, their etiology is still unclear. The relationship between environmental factors including diet and various skin diseases has been studied. The general mechanism of cadmium (Cd), lead (Pb) and mercury (Hg) toxicity is through the production of reactive oxygen species which are known to play a role in etiopathogenesis of skin disorders. Objective: The aim of this study was to estimate the influence of dietary habits on the concentration of Cd, Pb and Hg in the peripheral blood samples of patients with psoriasis and vitiligo. Methods: In this case-control study, sixty patients with psoriasis, fifty patients with vitiligo and fifty eight healthy people were examined. Blood levels of Cd, Pb and Hg were determined by atomic absorption spectrometry. Food-frequency questionnaires were implemented to collect the dietary data. Results: Significant differences (p < 0.05) of Cd levels were found between women and men with psoriasis and women and men in the control group. The concentration of Pb was significantly higher among vitiligo patients (50.04 = 26.54 mu g/L) than in healthy controls (36.04 +/- 27.35 mu g/L). Significantly lower ratio of Se/Pb, Zn/Pb and Cu/Pb was found among psoriatic men. Significantly (p < 0.05) lower values of Se/Hg ratio were observed among vitiligo patients compared to controls. Conclusions: The elevated levels of toxic elements could increase oxidative stress which may partly contribute to inflammation in the pathogenesis of psoriasis and vitiligo, which requires further research. Analysis of the influence of frequent consumption of food products on toxic metals concentration showed that the dietary habits have impact on the content of examined toxic metals in the blood of patients. The obtained results may be useful for composing the diet and could be helpful in prevention of psoriasis and vitiligo. (C) 2020 The Author(s). Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据