期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 284, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.resp.2020.103563
关键词
Respiratory rhythm; Respiratory pattern; Upper airway; Pneumotaxic center; Airflow; Postinspiration
资金
- National Health and Medical Research Council of Australia [APP1165529]
- Australian Research Council [DP170104861]
- Melbourne Research Scholarship (University of Melbourne) [181858]
Bilateral inhibition of the KFn triggers apneusis (prolonged inspiration) and abolishes pre-inspiratory discharge of facial, vagal and hypoglossal nerves as well as post-inspiratory discharge in the vagus.
The pontine Kolliker-Fuse nucleus (KFn) is a core nucleus of respiratory network that mediates the inspiratoryexpiratory phase transition and gates eupneic motor discharges in the vagal and hypoglossal nerves. In the present study, we investigated whether the same KFn circuit may also gate motor activities that control the resistance of the nasal airway, which is of particular importance in rodents. To do so, we simultaneously recorded phrenic, facial, vagal and hypoglossal cranial nerve activity in an in situ perfused brainstem preparation before and after bilateral injection of the GABA-receptor agonist isoguvacine (50-70 nl, 10 mM) into the KFn (n = 11). Our results show that bilateral inhibition of the KFn triggers apneusis (prolonged inspiration) and abolished pre-inspiratory discharge of facial, vagal and hypoglossal nerves as well as post-inspiratory discharge in the vagus. We conclude that the KFn plays a critical role for the eupneic regulation of naso-pharyngeal airway patency and the potential functions of the KFn in regulating airway patency and orofacial behavior is discussed.
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