Micro-XANES analysis of superparamagnetic iron-oxide nanoparticles in biological tissues

Micro - X-ray Absorption Near Edge Structure (mu XANES) at the Fe K-edge of biological tissues after admission of superparamagnetic iron oxide nanoparticles (SPIONs) has been used to monitor the iron oxidation state in the nanoparticles and in the native tissues. It was found that mu XANES technique with submicron spatial resolution is sensitive enough to allow a separation of the contributions from the iron atoms present in SPIONs from the contribution of the atoms representing iron contained in the tissues of the body before the introduction of nanoparticles. The analysis of mu XANES showed that SPIONs studied in the present research is found to be quite stable and retains its properties after interaction with tissues in vivo. Thus, such SPIONs are promising for further use in the theranostics for oncology.

Automated summary

The micro-X-ray Absorption Near Edge Structure (mu XANES) technique is used to monitor the iron oxidation state in superparamagnetic iron oxide nanoparticles (SPIONs) after they interact with biological tissues. The results show that SPIONs remain stable and retain their properties after interaction with tissues, suggesting their potential for use in oncology theranostics.