期刊
PSYCHONEUROENDOCRINOLOGY
卷 125, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2020.105118
关键词
Childhood adversity; HPA axis; Cortisol; Habituation; Sex; TSST
资金
- Provost Undergraduate Research Fund at Ohio University
- Honors Tutorial College at Ohio University
Childhood adversity may alter adult HPA axis habituation to repeated stress, potentially leading to sex differences. Future research should further investigate how HPA axis habituation to repeated stress may impact the effects of childhood adversity on adult health.
Background: Childhood adversity is a robust predictor of poor health outcomes in adulthood and hypothalamicpituitary-adrenocortical (HPA) axis dysfunction may be a key mechanism explaining this association. However, little is known about the influence childhood adversity may exhibit on adult HPA axis habituation (i.e., decreased cortisol output in response to a repeated stressor), where HPA axis dysfunction can be inferred if habituation deviates from normal patterns. Methods: The current study used data from a larger study that examined the effects of stress management interventions on cortisol habituation to repeated stress. Eighty-three adults reported childhood adversity with the Adverse Childhood Experience scale and completed the Trier Social Stress Test (TSST) twice (48 h apart) scheduled after a 6-wk intervention period. Salivary cortisol was assessed pre-stressor and +25, +35, and +60 mins post-stressor onset during both visits. Results: Results indicated that childhood adversity was associated with a marginally larger decrease in total cortisol from visit 1 to visit 2 among men (i.e., habituation), but not women (i.e. non-habituation). Conclusions: These findings suggest that childhood adversity may alter HPA axis habituation to repeated stress later in life, with possible sex differences. Future research should investigate whether HPA axis habituation to repeated stress may be a pathway through which childhood adversity affects adult health, and how it may affect men and women differently.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据