期刊
PROSTAGLANDINS & OTHER LIPID MEDIATORS
卷 152, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.prostaglandins.2020.106482
关键词
Arachidonic acid; Electrophiles; Cyclooxygenase; Lipoxygenase; Nitroalkenes; Nitro-fatty acids; Nitroarachidonic acid
资金
- Comision Sectorial de Investigacion Cientifica (CSIC, Grupo 536)-Uruguay
- Fondo Vaz Ferreira [FVF NS243-19]
- Proyectos de Investigacion con contrapartida financiadora 2019 (Empresa BIOTEN)
- Arturo Falaschi programme of the International Centre for Genetic Engineering and Biotechnology
- Comision Academica de Posgrado (CAP), Universidad de la Republica, Uruguay
Arachidonic acid serves as a precursor for various oxidized products with signaling or damaging roles in inflammation. Enzymes such as cyclooxygenases, lipoxygenases, and cytochrome P450 can convert arachidonic acid to lipid-derived electrophiles, which have potent signaling properties.
Arachidonic acid (AA) is a precursor of enzymatic and non-enzymatic oxidized products such as prostaglandins, thromboxanes, leukotrienes, lipoxins, and isoprostanes. These products may exert signaling or damaging roles during physiological and pathological conditions, some of them being markers of oxidative stress linked to inflammation. Recent data support the concept that cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 (CYP450) followed by cytosolic and microsomal dehydrogenases can convert AA to lipid-derived electrophiles (LDE). Lipid-derived electrophiles are fatty acid derivatives bearing an electron-withdrawing group that can react with nucleophiles at proteins, DNA, and small antioxidant molecules exerting potent signaling properties. This review aims to describe the formation, sources, and electrophilic anti-inflammatory actions of key mammalian LDE.
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