Covariance NMR: Theoretical concerns, practical considerations, contemporary applications and related techniques

The family of resolution enhancement and spectral reconstruction techniques collectively known as covariance NMR continues to expand, along with the list of applications for these techniques. Recent advances in covariance NMR include the utilization of covariance to reconstruct pure shift NMR spectra, and the growing use of covariance NMR in processing non-uniformly sampled data, especially in solid state NMR and metabolomics. This review describes theoretical and practical considerations for direct and indirect covariance NMR techniques, and summarizes recent additions to the covariance NMR family. The review also outlines some of the applications of covariance NMR, and places covariance NMR in the larger context of methods that use statistical and algebraic approaches to enhance and combine various kinds of spectroscopic data, including tensor-based approaches for multidimensional NMR and heterocovariance spectroscopy. (C) 2020 Elsevier B.V. All rights reserved.

Automated summary

Covariance NMR techniques are continuously expanding and being applied in areas such as reconstructing pure shift NMR spectra and processing non-uniformly sampled data. This review discusses theoretical and practical considerations for direct and indirect covariance NMR techniques and outlines recent additions to the covariance NMR family.