期刊
PROGRESS IN NEUROBIOLOGY
卷 201, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2021.102027
关键词
Hippocampal network; Olfactory system; Functional connectivity; fMRI; iEEG
资金
- National Institutes of Health [R00-DC-012803, R01-DC-016364, R01-NS-113804]
- Knut and Alice Wallenberg Foundation [KAW 2016:0229]
- Swedish Research Council [2020-00266]
- Swedish Research Council [2020-00266] Funding Source: Swedish Research Council
Research suggests that the human olfactory system has stronger connectivity with hippocampal networks at rest than other sensory systems, indicating potential retention of olfactory-hippocampal connections in mammalian evolution. Additionally, it was found that connectivity between olfaction and hippocampus oscillates with nasal breathing.
During mammalian evolution, primate neocortex expanded, shifting hippocampal functional networks away from primary sensory cortices, towards association cortices. Reflecting this rerouting, human resting hippocampal functional networks preferentially include higher association cortices, while those in rodents retained primary sensory cortices. Research on human visual, auditory and somatosensory systems shows evidence of this rerouting. Olfaction, however, is unique among sensory systems in its relative structural conservation throughout mammalian evolution, and it is unknown whether human primary olfactory cortex was subject to the same rerouting. We combined functional neuroimaging and intracranial electrophysiology to directly compare hippocampal functional networks across human sensory systems. We show that human primary olfactory cortex?including the anterior olfactory nucleus, olfactory tubercle and piriform cortex?has stronger functional connectivity with hippocampal networks at rest, compared to other sensory systems. This suggests that unlike other sensory systems, olfactory-hippocampal connectivity may have been retained in mammalian evolution. We further show that olfactory-hippocampal connectivity oscillates with nasal breathing. Our findings suggest olfaction might provide insight into how memory and cognition depend on hippocampal interactions.
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