期刊
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
卷 106, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2020.110173
关键词
Interleukin 8; Schizophrenia; Mood disorders; Alzheimer's disease; Cognition; Sleep
资金
- Taiwan Ministry of Science and Technology [MOST 109-2634-F-075-001]
- Taipei Veterans General Hospital2 [V108D44-001-MY3-1, V109C-196, VGHUST109-V1-2-1]
Low grade neuroinflammation, particularly involving interleukin-8 (IL-8), has been suggested as an underlying mechanism for various psychiatric diseases and cognitive disorders. Elevated peripheral levels of IL-8 have been reported in conditions such as schizophrenia, bipolar disorder, obstructive sleep apnea, and autism spectrum disorder. However, the exact role of IL-8 in major depression remains inconsistent in the literature.
Low grade neuroinflammation has been suggested as one of the underlying mechanisms of many psychiatric diseases as well as cognitive disorders. Interleukin 8 (IL-8), a proinflammatory cytokine produced by many cell types including macrophage and microglia, mainly functions as a neutrophil chemoattractant in the bloodstream. IL-8 is also found in the brain, where it is released from microglia in response to proinflammatory stimuli. In this review, we highlight studies focusing on the role of IL-8 in psychiatric diseases such as major depression, bipolar disorder, schizophrenia, sleep disorder, autism spectrum disorder, anxiety disorders and dementia. Increased peripheral IL-8 levels have been reported in these diseases, particularly in schizophrenic disorder, bipolar disorder, obstructive sleep apnea and autism spectrum disorder. The literature on IL-8 and major depression is inconsistent. IL-8 has been found to be a factor associated with schizophrenic prognosis and therapeutic response, and may affect a wide range of symptomatology. Considering that the exact role of immune alterations is still under research, the success of immune-based therapies in psychiatric diseases is limited for the time being.
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