期刊
ENVIRONMENT INTERNATIONAL
卷 94, 期 -, 页码 76-82出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2016.05.004
关键词
Air pollution; COPD; Exhaled airway markers; Respiratory symptom
资金
- National Natural Science Foundation of China [91543112, 81072267]
- Beijing Municipal Commission of Education [20131000109]
- Grants-in-Aid for Scientific Research [24406020] Funding Source: KAKEN
Background: Few studies have investigated the short-term respiratory effects of ambient air pollution in chronic obstructive pulmonary disease (COPD) patients in the context of high pollution levels in Asian cities. Methods: A panel of 23 stable COPD patients was repeatedly measured for biomarkers of airway inflammation including exhaled nitric oxide (FeNO) and exhaled hydrogen sulfide (FeH2S) (215 measurements) and recorded for daily respiratory symptoms (794person-days) in two study periods in Beijing, China in January-September 2014. Daily ambient air pollution data were obtained from nearby central air-monitoring stations. Mixed-effects models were used to estimate the associations between exposures and health measurements with adjustment for potential confounders including temperature and relative humidity. Results: Increasing levels of air pollutants were associated with significant increases in both FeNO and FeH2S. Interquartile range (IQR) increases in PM2.5 (76.5 mu g/m(3), 5-day), PM10 (75.0 mu g/m(3), 5-day) and SO2 (45.7 mu g/m(3), 6-day) were associated with maximum increases in FeNO of 13.6% (95% CI: 4.8%, 23.2%), 9.2% (95% CI: 2.1%, 16.8%) and 34.2% (95% CI: 17.3%, 53.4%), respectively; and the same IQR increases in PM2.5 (6-day), PM10 (6-day) and SO2 (7-day) were associated with maximum increases in FeH2S of 11.4% (95% CI: 4.6%, 18.6%), 7.8% (95% CI: 2.3%, 13.7%) and 18.1% (95% CI: 5.5%, 32.2%), respectively. Increasing levels of air pollutants were also associated with increased odds ratios of sore throat, cough, sputum, wheeze and dyspnea. Conclusions: FeH2S may serve as a novel biomarker to detect adverse respiratory effects of air pollution. Our results provide potential important public health implications that ambient air pollution may pose risk to respiratory health in the context of high pollution levels in densely-populated cities in the developing world. (C) 2016 Elsevier Ltd. All rights reserved.
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