期刊
ENVIRONMENT INTERNATIONAL
卷 97, 期 -, 页码 195-203出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2016.09.011
关键词
woodsmoke; household air pollution; stove intervention; polycyclic aromatic hydrocarbon; biomonitoring; 1-hydroxypyrene
资金
- Fogarty International Center, National Institutes on Environmental Health Services [5-D43TW005746-04]
- UBS Optimus Foundation [ISRCTN28191222]
- National Institute for Occupational Safety and Health through the University of Alabama, Birmingham [2T42OH008436]
- University of Georgia Graduate School and Interdisciplinary Toxicology Program
Background: Household air pollution (HAP) from indoor biomass stoves contains harmful pollutants, such as polycyclic aromatic hydrocarbons (PAHs), and is a leading risk factor for global disease burden. We used biomonitoring to assess HAP exposure and association with self-reported symptoms in 334 non-smoking Peruvian women to evaluate the efficacy of a stove intervention program. Methods: We conducted a cross-sectional study within the framework of a community randomized control trial. Using urinary PAH metabolites (OH-PAHs) as the exposure biomarkers, we investigated whether the intervention group (n = 155, with new chimney-equipped stoves) were less exposed to HAP compared to the control group (n = 179, with mostly open-fire stoves). We also estimated associations between the exposure biomarkers, risk factors, and self-reported health symptoms, such as recent eye conditions, respiratory conditions, and headache. Results: We observed reduced headache and ocular symptoms in the intervention group than the control group. Urinary 2-naphthol, a suggested biomarker for inhalation PAH exposure, was significantly lower in the intervention group (GM with 95% CI: 13.4 [12.3, 14.6] mu g/g creatinine) compared to control group (16.5 [15.0, 18.0] mu g/g creatinine). Stove type and/or 2-naphthol was associated with a number of self-reported symptoms, such as red eye (adjusted OR with 95% CI: 3.80 [1.32, 10.9]) in the past 48 h. Conclusions: Even with the improved stoves, the biomarker concentrations in this study far exceeded those of the general populations and were higher than a no-observed-genotoxic-effect-level, indicating high exposure and a potential for increased cancer risk in the population. Published by Elsevier Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据