期刊
PLOS ONE
卷 16, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0246067
关键词
-
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq 470959/2014-2, 405595/2016-6]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brasil (CAPES) [001]
Priapism, a urologic emergency often associated with sickle cell disease, was found to be linked with alterations in laboratory biomarkers and lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to have a lower risk of priapism. Multivariate analysis showed that low HbF and NOm were independently associated with priapism.
Priapism is a urologic emergency characterized by an uncontrolled, persistent and painful erection in the absence of sexual stimulation, which can lead to penile fibrosis and impotence. It is highly frequent in sickle cell disease (SCD) associated with hemolytic episodes. Our aim was to investigate molecules that may participate in the regulation of vascular tone. Eighty eight individuals with SCD were included, of whom thirty-seven reported a history of priapism. Priapism was found to be associated with alterations in laboratory biomarkers, as well as lower levels of HbF. Patients with sickle cell anemia using hydroxyurea and those who received blood products seemed to be less affected by priapism. Multivariate analysis suggested that low HbF and NOm were independently associated with priapism. The frequency of polymorphisms in genes NOS3 and EDN1 was not statistically significant between the studied groups, and the presence of the variant allele was not associated with alterations in NOm and ET-1 levels in patients with SCD. The presence of the variant allele in the polymorphisms investigated did not reveal any influence on the occurrence priapism. Future studies involving larger samples, as well as investigations including patients in priapism crisis, could contribute to an enhanced understanding of the development of priapism in SCD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据