期刊
PLANTA MEDICA
卷 88, 期 5, 页码 405-415出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1323-3622
关键词
Myrcia bella; Myrtaceae; biopharmaceuticals; biotechnology; antifungal; nanotechnology; mutagenicity
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 2016/08559-5, 2017/16278-9, 2017/18782-6, 2018/12590-0]
- National Council for Scientific and Technological Development (CNPq) [423371/2018-5]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
The study found that the Myrcia bella extract exhibited antimicrobial properties and suggested caution in its medicinal use. The incorporation of the extract into nanostructured lipid systems inhibited mutagenicity and showed important antifungal effects against Candida sp strains. This highlights the potential of using nanotechnology with natural products for controlling infections caused by Candida sp.
Myrcia bella is a medicinal plant used for the treatment of diabetes, hemorrhages, and hypertension in Brazilian folk medicine. Considering that plant extracts are attractive sources of new drugs, the aim of the present study was to verify the influence of incorporating 70% hydroalcoholic of M. bella leaves in nanostructured lipid systems on the mutagenic and antifungal activities of the extract. In this work, we evaluated the antifungal potential of M. bella loaded on the microemulsion against Candida sp for minimum inhibitory concentration, using the microdilution technique. The system was composed of polyoxyethylene 20 cetyl ether and soybean phosphatidylcholine (10%), grape seed oil, cholesterol (10%: proportion 5/1), and purified water (80%). To investigate the mutagenic activity, the Ames test was used with the Salmonella Typhimurium tester strains. M. bella, either incorporated or free, showed an important antifungal effect against all tested strains. Moreover, the incorporation surprisingly inhibited the mutagenicity presented by the extract. The present study attests the antimicrobial properties of M. bella extract, contributing to the search for new natural products with biological activities and suggesting caution in its use for medicinal purposes. In addition, the results emphasize the importance of the use of nanotechnology associated with natural products as a strategy for the control of infections caused mainly by the genus Candida sp.
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