期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 34, 期 4, 页码 777-785出版社
WILEY
DOI: 10.1111/pcmr.12969
关键词
cAMP; melanin; melanocortin 1 receptor; melanocyte; pigmentation
资金
- National Institute of Environmental Health Sciences [P30ES026529]
- National Cancer Institute [P30CA177558, R01CA131075]
Skin complexion is determined by the amount and type of melanin pigment in the epidermis, with darker skin having more eumelanin for natural sun protection. Understanding pigmentation regulation can lead to strategies for manipulating skin pigmentation to improve UV resistance and reduce skin cancer risk.
Skin complexion is among the most recognizable phenotypes between individuals and is mainly determined by the amount and type of melanin pigment deposited in the epidermis. Persons with dark skin complexion have more of a brown/black pigment known as eumelanin in their epidermis whereas those with fair skin complexions have less. Epidermal eumelanin acts as a natural sunblock by preventing incoming UV photons from penetrating into the skin and therefore protects against UV mutagenesis. By understanding the signaling pathways and regulation of pigmentation, strategies can be developed to manipulate skin pigmentation to improve UV resistance and to diminish skin cancer risk.
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