期刊
PHYTOTHERAPY RESEARCH
卷 35, 期 7, 页码 3447-3483出版社
WILEY
DOI: 10.1002/ptr.7039
关键词
2019‐ nCoV; antiviral chemotypes; medicinal plants; phytomolecules; viral infections
Researchers are increasingly focusing on using bioactive substances in herbal medicine as antiviral drugs to combat the challenges posed by viral infections like novel coronavirus. Compounds in herbal medicine can inhibit virus replication through various mechanisms, laying the groundwork for the future development of promising antiviral treatments.
The pandemic of viral diseases like novel coronavirus (2019-nCoV) prompted the scientific world to examine antiviral bioactive compounds rather than nucleic acid analogous, protease inhibitors, or other toxic synthetic molecules. The emerging viral infections significantly associated with 2019-nCoV have challenged humanity's survival. Further, there is a constant emergence of new resistant viral strains that demand novel antiviral agents with fewer side effects and cell toxicity. Despite significant progress made in immunization and regenerative medicine, numerous viruses still lack prophylactic vaccines and specific antiviral treatments that are so often influenced by the generation of viral escape mutants. Of importance, medicinal herbs offer a wide variety of therapeutic antiviral chemotypes that can inhibit viral replication by preventing viral adsorption, adhering to cell receptors, inhibiting virus penetration in the host cell, and competing for pathways of activation of intracellular signals. The present review will comprehensively summarize the promising antiviral activities of medicinal plants and their bioactive molecules. Furthermore, it will elucidate their mechanism of action and possible implications in the treatment/prevention of viral diseases even when their mechanism of action is not fully understood, which could serve as the base for the future development of novel or complementary antiviral treatments.
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