Three new diterpenoid alkaloids from Delphinium tatsienense

Three new diterpenoid alkaloids (DAs), including two lycaconitine-type C-19-DAs tatsiedines A and B (1 and 2) and a vakognavine-type C-20-DA tatsiedine C (3), have been isolated from the whole plants of Delphinium tatsienense Franch. (Ranunculaceae), a folk medicine for the treatment of wind-toxin syndrome in China. Their structures were established on the basis of extensive spectroscopic analyses. The isolated compounds were evaluated for their potential anti-inflammatory effects against NO production using LPS-stimulated RAW 264.7 macrophages.

Automated summary

Three new diterpenoid alkaloids were isolated from the whole plants of Delphinium tatsienense Franch., a folk medicine in China for wind-toxin syndrome treatment. The structures of these alkaloids were determined through extensive spectroscopic analyses. Their potential anti-inflammatory effects were evaluated against NO production in LPS-stimulated RAW 264.7 macrophages.