期刊
PHYTOCHEMISTRY
卷 182, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112596
关键词
Pistacia lentiscus; Anacardiaceae; Tirucallane triterpenoid; Anti-inflammatory; Cytotoxicity
资金
- National Natural Science Foundation of China [U1703331, 21502222]
- Jiangxi Shuangqian program [JXSQ2018101008]
Phytochemical investigation of mastic isolated and identified 16 tirucallane triterpenoids from resin produced by Pistacia lentiscus, including 13 undescribed compounds. Compounds 7, 8, 14, and 16 showed stronger anti-inflammatory activity, while compound 1 exhibited comparable cytotoxic activity against HepG2 cells to doxorubicin.
Phytochemical investigation of mastic, a resin produced by Pistacia lentiscus, led to the isolation and identification of 16 tirucallane triterpenoids, 13 (1-13) of which are undescribed. Their structures and absolute configurations were elucidated based on the analysis of spectroscopic data and single-crystal X-ray diffraction. Compounds 12 and 13 are unusual 7(8 -> 9)abeo-tirucallane triterpenoids. Anti-inflammatory assays indicated that compounds 7, 8, 14, and 16 exhibited stronger inhibitory NO production activities (IC50 = 7.7-13.4 mu M) than that of the positive control dexamethasone (IC50 = 19.5 mu M). In addition, compound 1 showed comparable cytotoxic activity against HepG2 cells to that of doxorubicin (IC50 = 4.92 VS 1.34 mu M).
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