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SCIENCE (2017)
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NATURE COMMUNICATIONS (2017)
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CELL REPORTS (2017)
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MYC Deregulation in Primary Human Cancers
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mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1
Joseph G. Moloughney et al.
MOLECULAR CELL (2016)
ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington's disease models
Mitchell S. Wold et al.
MOLECULAR NEURODEGENERATION (2016)
LKB1 loss links serine metabolism to DNA methylation and tumorigenesis
Filippos Kottakis et al.
NATURE (2016)
Autophagy maintains stemness by preventing senescence
Laura Garcia-Prat et al.
NATURE (2016)
The mTOR signalling cascade: paving new roads to cure neurological disease
Peter B. Crino
NATURE REVIEWS NEUROLOGY (2016)
microRNA-153 Targets mTORC2 Component Rictor to Inhibit Glioma Cells
Yan Cui et al.
PLOS ONE (2016)
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
Issam Ben-Sahra et al.
SCIENCE (2016)
The Warburg Effect: How Does it Benefit Cancer Cells?
Maria V. Liberti et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling
Lili Guo et al.
TUMOR BIOLOGY (2016)
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway
Melissa Carbonneau et al.
NATURE COMMUNICATIONS (2016)
Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
Mulki Angela et al.
NATURE COMMUNICATIONS (2016)
Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism
Yuefeng Tang et al.
NATURE COMMUNICATIONS (2016)
PI3K/Akt promotes feedforward mTORC2 activation through IKKα
Han C. Dan et al.
ONCOTARGET (2016)
Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
Jianchang Qian et al.
ONCOTARGET (2016)
Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen
Yujie Zhang et al.
SCIENTIFIC REPORTS (2016)
DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR
Goran Micevic et al.
CELL REPORTS (2016)
Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
Anthony J. Covarrubias et al.
ELIFE (2016)
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
Xinde Zheng et al.
eLife (2016)
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
Alessandro Bitto et al.
ELIFE (2016)
Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity
Alexandre Caron et al.
MOLECULAR METABOLISM (2016)
Metabolic Alterations Caused by KRAS Mutations in Colorectal Cancer Contribute to Cell Adaptation to Glutamine Depletion by Upregulation of Asparagine Synthetase
Kosuke Toda et al.
NEOPLASIA (2016)
Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism
Maitea Guridi et al.
SKELETAL MUSCLE (2016)
Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
Chang-Liang He et al.
SCIENTIFIC REPORTS (2016)
The small GTPases Ras and Rap1 bind to and control TORC2 activity
Ankita Khanna et al.
SCIENTIFIC REPORTS (2016)
Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
Fredrick J. Rosario et al.
SCIENTIFIC REPORTS (2016)
Targeting Cancer Metabolism - Revisiting the Warburg Effects
Quangdon Tran et al.
TOXICOLOGICAL RESEARCH (2016)
Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice
Vincent Hurez et al.
AGING CELL (2015)
The PTEN-AKT-mTOR/RICTOR Pathway in Nasal Natural Killer Cell Lymphoma Is Activated by miR-494-3p via PTEN But Inhibited by miR-142-3p via RICTOR
Hao-Hui Chen et al.
AMERICAN JOURNAL OF PATHOLOGY (2015)
FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells
Susanne Schuster et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)
A liaison between mTOR signaling, ribosome biogenesis and cancer
Antonio Gentilella et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2015)
EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition
Chiara Zucal et al.
BMC CANCER (2015)
Transforming somatic mutations of mammalian target of rapamycin kinase in human cancer
Hiroyuki Yamaguchi et al.
CANCER SCIENCE (2015)
Fission yeast Ryh1 GTPase activates TOR Complex 2 in response to glucose
Tomoyuki Hatano et al.
CELL CYCLE (2015)
mTOR signaling in cellular and organismal energetics
Verena Albert et al.
CURRENT OPINION IN CELL BIOLOGY (2015)
NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition
Hai-Xin Yuan et al.
GENES & DEVELOPMENT (2015)
Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling
Shanshan Gao et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2015)
Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation
Junghui Koo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
4E-BPs Control Fat Storage by Regulating the Expression of Egr1 and ATGL
Maneet Singh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Kristen N. Pollizzi et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation
Chang-Jun Li et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Defining the Domain Arrangement of the Mammalian Target of Rapamycin Complex Component Rictor Protein
Ping Zhou et al.
JOURNAL OF COMPUTATIONAL BIOLOGY (2015)
Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
Almas Siddiqui et al.
JOURNAL OF NEUROSCIENCE (2015)
Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
Jennifer Jung et al.
MOLECULAR AND CELLULAR BIOLOGY (2015)
mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer
Valerie L. Sodi et al.
MOLECULAR CANCER RESEARCH (2015)
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1
Jinbo Han et al.
NATURE (2015)
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
Manuele Rebsamen et al.
NATURE (2015)
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
Shiran Rabinovich et al.
NATURE (2015)
Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming
Yasong Wu et al.
NATURE CELL BIOLOGY (2015)
Reinstating Aberrant mTORC1 Activity in Huntington's Disease Mice Improves Disease Phenotypes
John H. Lee et al.
NEURON (2015)
Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance
Kenta Masui et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Shuyu Wang et al.
SCIENCE (2015)
Differential regulation of mTORC1 by leucine and glutamine
Jenna L. Jewell et al.
SCIENCE (2015)
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz et al.
SCIENCE SIGNALING (2015)
Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency
Hyunsoo Kim et al.
STEM CELLS (2015)
The role of mTOR in lipid homeostasis and diabetes progression
Partha Chakrabarti et al.
Current Opinion in Endocrinology Diabetes and Obesity (2015)
RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors
Haiying Cheng et al.
CANCER DISCOVERY (2015)
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
Pengda Liu et al.
CANCER DISCOVERY (2015)
mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation
Jong-Seok Moon et al.
CELL REPORTS (2015)
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
Guang Yang et al.
CELL REPORTS (2015)
Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice
Mark A. Smith et al.
Cell Reports (2015)
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz et al.
SCIENCE SIGNALING (2015)
mTOR links environmental signals to T cell fate decisions
Nicole M. Chapman et al.
FRONTIERS IN IMMUNOLOGY (2015)
Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling
Rongya Tao et al.
DIABETES (2015)
Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver
Zhen Yu et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2015)
mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3
K. M. Dodd et al.
ONCOGENE (2015)
Characterization of Sin1 Isoforms Reveals an mTOR-Dependent and Independent Function of Sin1γ
Yuanyang Yuan et al.
PLOS ONE (2015)
Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart
Dao-Fu Dai et al.
AGING CELL (2014)
Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet
Olga V. Leontieva et al.
AGING CELL (2014)
Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan
Dudley W. Lamming et al.
AGING CELL (2014)
Inhibition of mTOR affects protein stability of OGT
S. Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Suchithra Menon et al.
CELL (2014)
Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
Constantinos Demetriades et al.
CELL (2014)
The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the elF4B-Dependent Control of c-Myc Translation
Alfredo Csibi et al.
CURRENT BIOLOGY (2014)
Improving Type 2 Diabetes Through a Distinct Adrenergic Signaling Pathway Involving mTORC2 That Mediates Glucose Uptake in Skeletal Muscle
Masaaki Sato et al.
DIABETES (2014)
The hexosamine biosynthesis pathway and O-GlcNAcylation maintain insulin-stimulated PI3K-PKB phosphorylation and tumour cell growth after short-term glucose deprivation
David R. Jones et al.
FEBS JOURNAL (2014)
Differential Activation of mTOR Complex 1 Signaling in Human Brain with Mild to Severe Alzheimer's Disease
Yong-Xin Sun et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Characterization of the Raptor/ 4E-BP1 Interaction by Chemical Cross- linking Coupled with Mass Spectrometry Analysis*
Kimberly Coffman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins
Daniele Stracka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Metabolic Reprogramming of Macrophages GLUCOSE TRANSPORTER 1 (GLUT1)-MEDIATED GLUCOSE METABOLISM DRIVES A PROINFLAMMATORY PHENOTYPE
Alex J. Freemerman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Glucose-dependent de Novo Lipogenesis in B Lymphocytes A REQUIREMENT FOR ATP-CITRATE LYASE IN LIPOPOLYSACCHARIDE-INDUCED DIFFERENTIATION
Fay J. Dufort et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Control of Paip1-Eukayrotic Translation Initiation Factor 3 Interaction by Amino Acids through S6 Kinase
Yvan Martineau et al.
MOLECULAR AND CELLULAR BIOLOGY (2014)
Akt Phosphorylation and Regulation of Transketolase Is a Nodal Point for Amino Acid Control of Purine Synthesis
Arindam Saha et al.
MOLECULAR CELL (2014)
Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids
Amin Khalifeh-Soltani et al.
NATURE MEDICINE (2014)
Beneficial Metabolic Effects of Rapamycin Are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice
Kassem Makki et al.
PLOS ONE (2014)
mTORC2 Is Required for Rit-Mediated Oxidative Stress Resistance
Weikang Cai et al.
PLOS ONE (2014)
Catecholamine-induced lipolysis causes mTOR complex dissociation and inhibits glucose uptake in adipocytes
Garrett R. Mullins et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity
Shih-Chin Cheng et al.
SCIENCE (2014)
Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease
William M. Pryor et al.
SCIENCE SIGNALING (2014)
REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling
Michael D. Dennis et al.
SCIENCE SIGNALING (2014)
mTOR inhibition improves immune function in the elderly
Joan B. Mannick et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Stimulation of Somatic Cell Reprogramming by ERas-Akt-FoxO1 Signaling Axis
Yong Yu et al.
STEM CELLS (2014)
HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1-3 and PKM2
Alessandro Prigione et al.
STEM CELLS (2014)
A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
Brian C. Grabiner et al.
CANCER DISCOVERY (2014)
Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib
Nikhil Wagle et al.
CANCER DISCOVERY (2014)
Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth
Lei Wang et al.
CELL REPORTS (2014)
Rictor/mTORC2 Loss in the Myf5 Lineage Reprograms Brown Fat Metabolism and Protects Mice against Obesity and Metabolic Disease
Chien-Min Hung et al.
CELL REPORTS (2014)
Rictor/mTORC2 facilitates central regulation of energy and glucose homeostasis
Heidi E. Kocalis et al.
MOLECULAR METABOLISM (2014)
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia
Lise Willems et al.
BLOOD (2013)
The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4
Alfred Csibi et al.
CELL (2013)
WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation
Emel Esen et al.
CELL METABOLISM (2013)
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
Masahiro Morita et al.
CELL METABOLISM (2013)
mTOR Complex 2 Controls Glycolytic Metabolism in Glioblastoma through FoxO Acetylation and Upregulation of c-Myc
Kenta Masui et al.
CELL METABOLISM (2013)
Cellular Fatty Acid Metabolism and Cancer
Erin Currie et al.
CELL METABOLISM (2013)
Transient Activation of Autophagy via Sox2-Mediated Suppression of mTOR Is an Important Early Step in Reprogramming to Pluripotency
Shuo Wang et al.
CELL STEM CELL (2013)
IKK interacts with rictor and regulates mTORC2
Yuanfei Xu et al.
CELLULAR SIGNALLING (2013)
PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes
Chen Li et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
T Cell Exit from Quiescence and Differentiation into Th2 Cells Depend on Raptor-mTORC1-Mediated Metabolic Reprogramming
Kai Yang et al.
IMMUNITY (2013)
Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism
Chien-Hung Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
Gregg L. Semenza
JOURNAL OF CLINICAL INVESTIGATION (2013)
Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson's Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy
Tian-Fang Jiang et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2013)
Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells
Fredrick J. Rosario et al.
JOURNAL OF PHYSIOLOGY-LONDON (2013)
Arginine Deiminase Resistance in Melanoma Cells Is Associated with Metabolic Reprogramming, Glucose Dependence, and Glutamine Addiction
Yan Long et al.
MOLECULAR CANCER THERAPEUTICS (2013)
Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex
Sang Gyun Kim et al.
MOLECULAR CELL (2013)
K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells
Juan F. Linares et al.
MOLECULAR CELL (2013)
mTOR kinase structure, mechanism and regulation
Haijuan Yang et al.
NATURE (2013)
mTORC1 couples immune signals and metabolic programming to establish Treg-cell function
Hu Zeng et al.
NATURE (2013)
Sinl phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
Pengda Liu et al.
NATURE CELL BIOLOGY (2013)
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
Yoko Kidani et al.
NATURE IMMUNOLOGY (2013)
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
Linda V. Sinclair et al.
NATURE IMMUNOLOGY (2013)
Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice
Aika Nojima et al.
PLOS ONE (2013)
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Michael Pourdehnada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology
Charles Betz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1
Issam Ben-Sahra et al.
SCIENCE (2013)
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Aaron M. Robitaille et al.
SCIENCE (2013)
mTOR Inhibition Alleviates Mitochondrial Disease in a Mouse Model of Leigh Syndrome
Simon C. Johnson et al.
SCIENCE (2013)
A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
Liron Bar-Peled et al.
SCIENCE (2013)
BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation
Yixin Yao et al.
SCIENCE SIGNALING (2013)
Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae
Joseph I. Kliegman et al.
CELL REPORTS (2013)
Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes
Akio Nakashima et al.
JOURNAL OF BIOMEDICAL SCIENCE (2013)
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition
Michele Cea et al.
BLOOD (2012)
Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
Megan J. Bywater et al.
CANCER CELL (2012)
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1
Liron Bar-Peled et al.
CELL (2012)
FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake
Hongxia Ren et al.
CELL (2012)
Staying alive Metabolic adaptations to quiescence
James R. Valcourt et al.
CELL CYCLE (2012)
Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
Asami Hagiwara et al.
CELL METABOLISM (2012)
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
A. D. Barlow et al.
DIABETOLOGIA (2012)
HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition
Wenyu Zhou et al.
EMBO JOURNAL (2012)
V-AKT murine thymoma viral oncogene homolog/mammalian target of rapamycin activation induces a module of metabolic changes contributing to growth in insulin-induced hepatocarcinogenesis
Matthias Evert et al.
HEPATOLOGY (2012)
mTOR, metabolism, and the regulation of T-cell differentiation and function
Adam T. Waickman et al.
IMMUNOLOGICAL REVIEWS (2012)
Metabolic switching and fuel choice during T-cell differentiation and memory development
Gerritje J. W. van der Windt et al.
IMMUNOLOGICAL REVIEWS (2012)
Glucose-6-phosphate dehydrogenase, NADPH, and cell survival
Robert C. Stanton
IUBMB LIFE (2012)
Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein
Emily J. Glidden et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Role of p70S6K1-mediated Phosphorylation of eIF4B and PDCD4 Proteins in the Regulation of Protein Synthesis
Michael D. Dennis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Osmotic Stress Regulates Mammalian Target of Rapamycin (mTOR) Complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor Protein Phosphorylation
Dongoh Kwak et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2
Minsheng Yuan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: Assembly of a multiprotein signaling complex
Uma K. Misra et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
mTOR Complex 2 Regulates Proper Turnover of Insulin Receptor Substrate-1 via the Ubiquitin Ligase Subunit Fbw8
Sung Jin Kim et al.
MOLECULAR CELL (2012)
Glutaminolysis Activates Rag-mTORC1 Signaling
Raul V. Duran et al.
MOLECULAR CELL (2012)
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
Christian C. Dibble et al.
MOLECULAR CELL (2012)
Metabolic checkpoints in activated T cells
Ruoning Wang et al.
NATURE IMMUNOLOGY (2012)
PI3K signalling: the path to discovery and understanding
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer
Yu Wang et al.
ONCOLOGY REPORTS (2012)
Distinct perturbation of the translatome by the antidiabetic drug metformin
Ola Larsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
Joshua L. Owen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Dudley W. Lamming et al.
SCIENCE (2012)
Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
Dania Daye et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)
Regulation and function of mTOR signalling in T cell fate decisions
Hongbo Chi
NATURE REVIEWS IMMUNOLOGY (2012)
Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells
Taotao Chen et al.
AGING CELL (2011)
Amino Acid Signaling in TOR Activation
Joungmok Kim et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
mTORC2 targets AGC kinases through Sin1-dependent recruitment
Angus J. M. Cameron et al.
BIOCHEMICAL JOURNAL (2011)
Lactate Dehydrogenase B Is Critical for Hyperactive mTOR-Mediated Tumorigenesis
Xiaojun Zha et al.
CANCER RESEARCH (2011)
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
Weibo Luo et al.
CELL (2011)
Activation of mTORC2 by Association with the Ribosome
Vittoria Zinzalla et al.
CELL (2011)
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
Timothy R. Peterson et al.
CELL (2011)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c
Min Wan et al.
CELL METABOLISM (2011)
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
Jessica L. Yecies et al.
CELL METABOLISM (2011)
Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming
Clifford D. L. Folmes et al.
CELL METABOLISM (2011)
Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
Yanyun Gu et al.
DIABETES (2011)
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang et al.
IMMUNITY (2011)
Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling
Irantzu Tato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel
Ming Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Phosphorylation of Raptor by p38β Participates in Arsenite-induced Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation
Xiao-Nan Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
Xiaoqing Gan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
Lewis Z. Shi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
Amparo Wolf et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression
Bilgen Ekim et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
Abdelhafid Saci et al.
MOLECULAR CELL (2011)
p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
Angeles Duran et al.
MOLECULAR CELL (2011)
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Joungmok Kim et al.
NATURE CELL BIOLOGY (2011)
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
Greg M. Delgoffe et al.
NATURE IMMUNOLOGY (2011)
Rapamycin passes the torch: a new generation of mTOR inhibitors
Don Benjamin et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction
M. Colombi et al.
ONCOGENE (2011)
Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts
Sandra Varum et al.
PLOS ONE (2011)
Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiency
Preeti Tandon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
Qian Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
Yonghao Yu et al.
SCIENCE (2011)
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu et al.
SCIENCE (2011)
ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β-Mediated Phosphorylation of Rictor
Chien-Hung Chen et al.
SCIENCE SIGNALING (2011)
B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses
Milena Bertolotti et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy
Itay Koren et al.
CURRENT BIOLOGY (2010)
Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage
Partha Chakrabarti et al.
DIABETES (2010)
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
Won Jun Oh et al.
EMBO JOURNAL (2010)
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
Hiroyuki Takai et al.
GENES & DEVELOPMENT (2010)
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
Kathryn E. Wellen et al.
GENES & DEVELOPMENT (2010)
Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas
Marie E. Beckner et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
Ghada A. Soliman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Regulation of mTOR Complex 1 (mTORC1) by Raptor Ser(863) and Multisite Phosphorylation
Kathryn G. Foster et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells
Boris Shor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
Louis-Andre Julien et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Katrin Duevel et al.
MOLECULAR CELL (2010)
Rictor is a novel target of p70 S6 kinase-1
C. Treins et al.
ONCOGENE (2010)
Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer
T. Sato et al.
ONCOGENE (2010)
Raptor is Phosphorylated by cdc2 during Mitosis
Dana M. Gwinn et al.
PLOS ONE (2010)
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
Shijie Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
Macus Tien Kuo et al.
ONCOTARGET (2010)
TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
Jeremy Copp et al.
CANCER RESEARCH (2009)
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Paul Nicklin et al.
CELL (2009)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
Metabolism, Cell Surface Organization, and Disease
James W. Dennis et al.
CELL (2009)
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes
Shigeyki Nada et al.
EMBO JOURNAL (2009)
The Phosphatidylinositol 3-Kinase/Akt Cassette Regulates Purine Nucleotide Synthesis
Wei Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin
Alfredo Toschi et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1
Christian C. Dibble et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth
Hugo A. Acosta-Jaquez et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
mTOR regulates memory CD8 T-cell differentiation
Koichi Araki et al.
NATURE (2009)
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
NATURE (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
Leona Plum et al.
NATURE MEDICINE (2009)
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
Hui H. Zhang et al.
PLOS ONE (2009)
Direct control of mitochondrial function by mTOR
Arvind Ramanathan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman et al.
SCIENCE (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
Chong Chen et al.
SCIENCE SIGNALING (2009)
Is Akt the Warburg kinase?-Akt-energy metabolism interactions and oncogenesis
R. Brooks Robey et al.
SEMINARS IN CANCER BIOLOGY (2009)
The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake
Xiuyun Jiang et al.
AMERICAN JOURNAL OF PATHOLOGY (2008)
A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression
Carolyn L. Buller et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)
TOR regulation of AGC kinases in yeast and mammals
Estela Jacinto et al.
BIOCHEMICAL JOURNAL (2008)
Multiple signaling pathways promote B lymphocyte stimulator-dependent B-cell growth and survival
Robert T. Woodland et al.
BLOOD (2008)
ATP Citrate Lyase: Activation and Therapeutic Implications in Non-Small Cell Lung Cancer
Toshiro Migita et al.
CANCER RESEARCH (2008)
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
Thomas Porstmann et al.
CELL METABOLISM (2008)
Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis
Clemence Blouet et al.
CELL METABOLISM (2008)
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
C. Florian Bentzinger et al.
CELL METABOLISM (2008)
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
Ralph J. DeBerardinis et al.
CELL METABOLISM (2008)
Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated Raptor phosphorylation
Audrey Carriere et al.
CURRENT BIOLOGY (2008)
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
Tsuneo Ikenoue et al.
EMBO JOURNAL (2008)
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
Valeria Facchinetti et al.
EMBO JOURNAL (2008)
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
Maurice Phillip DeYoung et al.
GENES & DEVELOPMENT (2008)
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
Hiraku Ono et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways
Sarah R. Jacobs et al.
JOURNAL OF IMMUNOLOGY (2008)
AMPK phosphorylation of raptor mediates a metabolic checkpoint
Dana M. Gwinn et al.
MOLECULAR CELL (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
Andrew Y. Choo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
Jian-Hua Mao et al.
SCIENCE (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR
V. Veverka et al.
ONCOGENE (2008)
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor
Janine Masri et al.
CANCER RESEARCH (2007)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
Nicholas F. Brown et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2007)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez et al.
NATURE REVIEWS CANCER (2007)
Role of the PI3-kinase/m Tor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver
Daniel Mauvoisin et al.
JOURNAL OF CELL COMMUNICATION AND SIGNALING (2007)
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
Bruno D. Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation
John D. Gordan et al.
CANCER CELL (2007)
Hypoxia-inducible factor 1α is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif
Stephen C. Land et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The proline-rich akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
Noriko Oshiro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling
Wayne A. Schroder et al.
CELLULAR SIGNALLING (2007)
A high glycolytic flux supports the proliferative potential of murine embryonic stem cells
Hiroshi Kondoh et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar et al.
NATURE CELL BIOLOGY (2007)
Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
Ian J. Sipula et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2006)
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
Qian Yang et al.
GENES & DEVELOPMENT (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2006)
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
Maria A. Frias et al.
CURRENT BIOLOGY (2006)
The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity
Stefan M. Schieke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
SIRT4 inhibits glutamate dehydrogehase and opposes the effects of calorie restriction in pancreatic β cells
Marcia C. Haigis et al.
CELL (2006)
Hypothalamic mTOR signaling regulates food intake
D Cota et al.
SCIENCE (2006)
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
KE O'Reilly et al.
CANCER RESEARCH (2006)
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
GV Thomas et al.
NATURE MEDICINE (2006)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
Li Ma et al.
CELL (2006)
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
A Tzatsos et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
Cheryl A. Doughty et al.
BLOOD (2006)
Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
BC Fuchs et al.
SEMINARS IN CANCER BIOLOGY (2005)
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
MK Holz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
L Ma et al.
CELL (2005)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
L Khamzina et al.
ENDOCRINOLOGY (2005)
Restraining PI3K: mTOR signalling goes back to the membrane
LS Harrington et al.
TRENDS IN BIOCHEMICAL SCIENCES (2005)
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
SWY Cheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
mTOR-dependent activation of the transcription factor TIMA links rRNA synthesis to nutrient availability
C Mayer et al.
GENES & DEVELOPMENT (2004)
Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene
W Schroder et al.
GENE (2004)
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
PP Roux et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
SH Um et al.
NATURE (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
PK Majumder et al.
NATURE MEDICINE (2004)
Akt stimulates aerobic glycolysis in cancer cells
RL Elstrom et al.
CANCER RESEARCH (2004)
mTOR-Dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
KM Hannan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
JB Brugarolas et al.
CANCER CELL (2003)
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
A Garami et al.
MOLECULAR CELL (2003)
Rapamycin induces Smad activity in prostate cancer cell lines
HG van der Poel et al.
UROLOGICAL RESEARCH (2003)
The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes
DC Berwick et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
R Loewith et al.
MOLECULAR CELL (2002)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
HS Lu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics
A Grolleau et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load
TH Reynolds et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
BN Desai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin
TA Huffman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Phosphatidic acid-mediated mitogenic activation of mTOR signaling
YM Fang et al.
SCIENCE (2001)
Mammalian TOR: A homeostatic ATP sensor
PB Dennis et al.
SCIENCE (2001)
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis:: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
E Laughner et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
K Gottlob et al.
GENES & DEVELOPMENT (2001)
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
HB Zhang et al.
GENES & DEVELOPMENT (2000)
TOR, a central controller of cell growth
T Schmelzle et al.
CELL (2000)
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
RT Peterson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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