期刊
PHYSICAL REVIEW LETTERS
卷 126, 期 8, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.126.088003
关键词
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资金
- European Research Council (ERC) under the European Union's Horizon 2020 Research and Innovation Programme [853560]
- Springboard Award from the Academy of Medical Sciences
- Global Challenges Research Fund [SBF003\1160]
- European Research Council (ERC) [853560] Funding Source: European Research Council (ERC)
This study demonstrates that the rolling motion of the biflagellate Chlamydomonas reinhardtii during swimming is derived from a nonplanar flagellar beat pattern, and a 3D model is constructed to explain this phenomenon. It is found that helical swimming requires further symmetry breaking between the two flagella, which is crucial for phototactic responses.
Helical swimming is a ubiquitous strategy for motile cells to generate self-gradients for environmental sensing. The model biflagellate Chlamydomonas reinhardtii rotates at a constant 1-2 Hz as it swims, but the mechanism is unclear. Here, we show unequivocally that the rolling motion derives from a persistent, nonplanar flagellar beat pattern. This is revealed by high-speed imaging and micromanipulation of live cells. We construct a fully 3D model to relate flagellar beating directly to the free-swimming trajectories. For realistic geometries, the model reproduces both the sense and magnitude of the axial rotation of live cells. We show that helical swimming requires further symmetry breaking between the two flagella. These functional differences underlie all tactic responses, particularly phototaxis. We propose a control strategy by which cells steer toward or away from light by modulating the sign of biflagellar dominance.
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