期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 201, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2021.173113
关键词
Fiber photometry; Neuronal circuits; Genetically-encoded biosensor; Electrochemical biosensor; Brain mapping; Neurotransmission
The review discusses the recent advances in monitoring and recording neurotransmission in freely moving animals using fiber photometry and electrochemical biosensors. These techniques provide high temporal and spatial resolution for measuring key neuronal transmission events specific to cell types or neurotransmitters of interest, complementing other techniques in the neuroscientist's toolbox.
To understand the correlation between animal behaviors and the underlying neuronal circuits, it is important to monitor and record neurotransmission in the brain of freely moving animals. With the development of fiber photometry, based on genetically encoded biosensors, and novel electrochemical biosensors, it is possible to measure some key neuronal transmission events specific to cell types or neurotransmitters of interest with high temporospatial resolution. This review discusses the recent advances and achievements of these two techniques in the study of neurotransmission in animal models and how they can be used to complement other techniques in the neuroscientist's toolbox.
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