4.6 Review

Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical Species

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years

Haeyoung Zhang et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2020)

Article Pharmacology & Pharmacy

Consequences of Phenytoin Exposure on Hepatic Cytochrome P450 Expression during Postnatal Liver Maturation in Mice

Stephanie C. Piekos et al.

DRUG METABOLISM AND DISPOSITION (2018)

Article Pharmacology & Pharmacy

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex

Deepak Kumar Bhatt et al.

DRUG METABOLISM AND DISPOSITION (2018)

Article Pharmacology & Pharmacy

Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants

Bianca D. van Groen et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Article Pharmacology & Pharmacy

Hepatic expression of transcription factors affecting developmental regulation of UGT1A1 in the Han Chinese population

Ya-li Nie et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2017)

Article Pharmacology & Pharmacy

Genetic and Nongenetic Factors Associated with Protein Abundance of Flavin-Containing Monooxygenase 3 in Human Liver

Meijuan Xu et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Article Medicine, Research & Experimental

Ontogeny, aging, and gender-related changes in hepatic multidrug resistant protein genes in rats

Qiong-Ni Zhu et al.

LIFE SCIENCES (2017)

Article Medicine, Research & Experimental

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes

Christine Wegler et al.

MOLECULAR PHARMACEUTICS (2017)

Article Chemistry, Multidisciplinary

In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Gottingen Minipigs

Els Van Peer et al.

PHARMACEUTICAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Age-dependent Protein Abundance of Cytosolic Alcohol and Aldehyde Dehydrogenases in Human Liver

Deepak Kumar Bhatt et al.

DRUG METABOLISM AND DISPOSITION (2017)

Article Pharmacology & Pharmacy

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children

David Hahn et al.

DRUG METABOLISM AND DISPOSITION (2017)

Article Biochemistry & Molecular Biology

The immature rat as a potential model for chemical risks to children: Ontogeny of selected hepatic P450s

Brooks T. McPhail et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2016)

Article Pharmacology & Pharmacy

Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics

B. Prasad et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2016)

Article Cell & Tissue Engineering

Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals

Sathidpak Nantasanti et al.

STEM CELLS TRANSLATIONAL MEDICINE (2016)

Article Pharmacology & Pharmacy

Age-Dependent Hepatic UDP-Glucuronosyltransferase Gene Expression and Activity in Children

Elizabeth Neumann et al.

FRONTIERS IN PHARMACOLOGY (2016)

Article Multidisciplinary Sciences

Comment: The FAIR Guiding Principles for scientific data management and stewardship

Mark D. Wilkinson et al.

SCIENTIFIC DATA (2016)

Article Pharmacology & Pharmacy

Calorie Restriction Increases P-Glycoprotein and Decreases Intestinal Absorption of Digoxin in Mice

Helen J. Renaud et al.

DRUG METABOLISM AND DISPOSITION (2016)

Article Pharmacology & Pharmacy

Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny

Ronald N. Hines et al.

DRUG METABOLISM AND DISPOSITION (2016)

Article Pharmacology & Pharmacy

Expression Patterns of Organic Anion Transporting Polypeptides 1B1 and 1B3 Protein in Human Pediatric Liver

Margaret M. S. Thomson et al.

DRUG METABOLISM AND DISPOSITION (2016)

Article Pharmacology & Pharmacy

Age-Specific Regulation of Drug-Processing Genes in Mouse Liver by Ligands of Xenobiotic-Sensing Transcription Factors

Cindy Yanfei Li et al.

DRUG METABOLISM AND DISPOSITION (2016)

Review Pharmacology & Pharmacy

Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics

Yasmine Elmorsi et al.

DRUG METABOLISM AND DISPOSITION (2016)

Article Pharmacology & Pharmacy

Age-related Differences in CYP3A Abundance and Activity in the Liver of the Gottingen Minipig

Els Van Peer et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2015)

Review Pharmacology & Pharmacy

Human Ontogeny of Drug Transporters: Review and Recommendations of the Pediatric Transporter Working Group

K. L. R. Brouwer et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

Article Biochemistry & Molecular Biology

Interplay of Drug-Metabolizing Enzymes and Transporters in Drug Absorption and Disposition

Shaojun Shi et al.

CURRENT DRUG METABOLISM (2015)

Article Veterinary Sciences

Weak activity of UDP-glucuronosyltransferase toward Bisphenol analogs in mouse perinatal development

Risa Yabusaki et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2015)

Article Genetics & Heredity

Genetic variation, expression and ontogeny of sulfotransferase SULT2A1 in humans

L. Ekstrom et al.

PHARMACOGENOMICS JOURNAL (2015)

Article Toxicology

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

Felcy Pavithra Selwyn et al.

TOXICOLOGICAL SCIENCES (2015)

Article Pharmacology & Pharmacy

Age-related changes in mRNA levels of hepatic transporters, cytochrome P450 and UDP-glucuronosyltransferase in female rats

Atsushi Kawase et al.

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS (2015)

Article Biotechnology & Applied Microbiology

What do drug transporters really do?

Sanjay K. Nigam

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Pharmacology & Pharmacy

Age-Dependent Activity of the Uptake Transporters Ntcp and Oatp1b2 in Male Rat Hepatocytes: From Birth Till Adulthood

Sarinj Fattah et al.

DRUG METABOLISM AND DISPOSITION (2015)

Article Pharmacology & Pharmacy

Ontogeny of CYP3A and P-Glycoprotein in the Liver and the Small Intestine of the Gottingen Minipig: An Immunohistochemical Evaluation

Els Van Peer et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2014)

Article Toxicology

Human Hepatic UGT2B15 Developmental Expression

Karthika Divakaran et al.

TOXICOLOGICAL SCIENCES (2014)

Article Pharmacology & Pharmacy

Age- and sex-related differences of organic anion-transporting polypeptide gene expression in livers of rats

Wei-Yu Hou et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

Article Pharmacology & Pharmacy

Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development

A. R. Maharaj et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2014)

Article Pharmacology & Pharmacy

Ontogeny of Human Hepatic and Intestinal Transporter Gene Expression during Childhood: Age Matters

Miriam G. Mooij et al.

DRUG METABOLISM AND DISPOSITION (2014)

Review Pharmacology & Pharmacy

Renal Transporters in Drug Development

Kari M. Morrissey et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)

Editorial Material Pharmacology & Pharmacy

Transporters in Drug Development and Clinical Pharmacology

K. M. Giacomini et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)

Article Pharmacology & Pharmacy

Drug disposition and clinical practice in neonates: Cross talk between developmental physiology and pharmacology

Anne Smits et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Editorial Material Biochemical Research Methods

Western Blots versus Selected Reaction Monitoring Assays: Time to Turn the Tables?

Ruedi Aebersold et al.

MOLECULAR & CELLULAR PROTEOMICS (2013)

Article Pharmacology & Pharmacy

RNA-Sequencing Quantification of Hepatic Ontogeny of Phase-I Enzymes in Mice

Lai Peng et al.

DRUG METABOLISM AND DISPOSITION (2013)

Article Pharmacology & Pharmacy

RNA-Sequencing Quantification of Hepatic Ontogeny and Tissue Distribution of mRNAs of Phase II Enzymes in Mice

Hong Lu et al.

DRUG METABOLISM AND DISPOSITION (2013)

Review Pharmacology & Pharmacy

Drug Transporters in Drug Efficacy and Toxicity

M. K. DeGorter et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)

Article Pharmacology & Pharmacy

Ontogeny of Novel Cytochrome P450 Gene Isoforms during Postnatal Liver Maturation in Mice

Julia Yue Cui et al.

DRUG METABOLISM AND DISPOSITION (2012)

Article Pharmacology & Pharmacy

Higher clearance of micafungin in neonates compared with adults: role of age-dependent micafungin serum binding

Souzan B. Yanni et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2011)

Article Pharmacology & Pharmacy

The Development of UDP-Glucuronosyltransferases 1A1 and 1A6 in the Pediatric Liver

Shogo J. Miyagi et al.

DRUG METABOLISM AND DISPOSITION (2011)

Article Pharmacology & Pharmacy

Expression of Cytochromes P450 in Fetal, Infant, and Juvenile Liver of Cynomolgus Macaques

Ryota Ise et al.

DRUG METABOLISM AND PHARMACOKINETICS (2011)

Article Cardiac & Cardiovascular Systems

Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients

Violette Gijsen et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2011)

Article Cell Biology

Differential expression of ABC transporters (MDR1, MRP1, BCRP) in developing human embryos

A. Konieczna et al.

JOURNAL OF MOLECULAR HISTOLOGY (2011)

Article Pharmacology & Pharmacy

Human Liver Expression of CYP2C8: Gender, Age, and Genotype Effects

Suresh Babu Naraharisetti et al.

DRUG METABOLISM AND DISPOSITION (2010)

Article Veterinary Sciences

Changes in the Gene Expression and Enzyme Activity of Hepatic Cytochrome P450 in Juvenile Sprague-Dawley Rats

Yoshiji Asaoka et al.

JOURNAL OF VETERINARY MEDICAL SCIENCE (2010)

Review Urology & Nephrology

A 'complexity' of urate transporters

Alan F. Wright et al.

KIDNEY INTERNATIONAL (2010)

Review Pharmacology & Pharmacy

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

Curtis D. Klaassen et al.

PHARMACOLOGICAL REVIEWS (2010)

Article Pharmacology & Pharmacy

Morphine Glucuronidation in Preterm Neonates, Infants and Children Younger than 3 Years

Catherijne A. J. Knibbe et al.

CLINICAL PHARMACOKINETICS (2009)

Review Pharmacology & Pharmacy

Challenges for drug studies in children: CYP3A phenotyping as example

Saskia N. de Wildt et al.

DRUG DISCOVERY TODAY (2009)

Article Pharmacology & Pharmacy

Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver

Hao-Jie Zhu et al.

DRUG METABOLISM AND DISPOSITION (2009)

Article Pharmacology & Pharmacy

mRNA Expression of MDR1 and Major Metabolising Enzymes in Human Fetal Tissues

May Fakhoury et al.

DRUG METABOLISM AND PHARMACOKINETICS (2009)

Article Veterinary Sciences

Ontogeny of glutathione and glutathione-related antioxidant enzymes in rat liver

Fawzy Elbarbry et al.

RESEARCH IN VETERINARY SCIENCE (2009)

Article Biochemical Research Methods

Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility

Amelie Lupp et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Ontogenic isoform switching of UDP-glucuronosyltransferase family 1 in rat liver

Mariko Kishi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)

Article Pharmacology & Pharmacy

Systemic Functional Expression of N-Acetyltransferase Polymorphism in the F344 Nat2 Congenic Rat

David W. Hein et al.

DRUG METABOLISM AND DISPOSITION (2008)

Article Pharmacology & Pharmacy

Developmental changes in human liver CYP2D6 expression

Jeffrey C. Stevens et al.

DRUG METABOLISM AND DISPOSITION (2008)

Article Pharmacology & Pharmacy

Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype

J. Steven Leeder et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2008)

Article Reproductive Biology

The ontogeny of drug metabolizing enzymes and transporters in the rat

Loeckie de Zwart et al.

REPRODUCTIVE TOXICOLOGY (2008)

Article Pharmacology & Pharmacy

Regulation of hepatic bile acid transporters Ntcp and Bsep expression

Xinqquo Cheng et al.

BIOCHEMICAL PHARMACOLOGY (2007)

Article Pharmacology & Pharmacy

Evaluation of the assumptions of an ontogeny model of rat hepatic cytochrome p450 activity

Jane Alcorn et al.

DRUG METABOLISM AND DISPOSITION (2007)

Article Pharmacology & Pharmacy

Pediatric development of glucuronidation: The ontogeny of hepatic UGT1A4

Shogo J. Miyagi et al.

DRUG METABOLISM AND DISPOSITION (2007)

Article Biochemistry & Molecular Biology

Ontogenic development-associated changes in the expression of genes involved in rat bile acid homeostasis

Susana Cuesta de Juan et al.

JOURNAL OF LIPID RESEARCH (2007)

Article Biochemistry & Molecular Biology

Ontogeny of hepatic CYP1A2 and CYP2E1 expression in rat

Fawzy A. Elbarbry et al.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2007)

Article Pharmacology & Pharmacy

Epirubicin glucuronidation and UGT2B7 developmental expression

Matthew J. Zaya et al.

DRUG METABOLISM AND DISPOSITION (2006)

Article Toxicology

Tissue distribution and ontogeny of sulfotransferase enzymes in mice

Yazen Alnouti et al.

TOXICOLOGICAL SCIENCES (2006)

Article Pharmacology & Pharmacy

Drug transporters in pharmacokinetics

E Petzinger et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2006)

Article Pharmacology & Pharmacy

Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre- and postnatal human liver

ZB Duanmu et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)

Review Pharmacology & Pharmacy

Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

Trevor N. Johnson et al.

CLINICAL PHARMACOKINETICS (2006)

Article Gastroenterology & Hepatology

Developmental expression of canalicular transporter genes in human liver

HL Chen et al.

JOURNAL OF HEPATOLOGY (2005)

Article Pharmacology & Pharmacy

Variability of CYP3A7 expression in human fetal liver

JS Leeder et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Pharmacology & Pharmacy

Tissue distribution and ontogeny of mouse organic anion transporting polypeptides (Oatps)

XG Cheng et al.

DRUG METABOLISM AND DISPOSITION (2005)

Article Cell Biology

Ontogeny of the neutral amino acid transporter SNAT1 in the developing rat

MD Weiss et al.

JOURNAL OF MOLECULAR HISTOLOGY (2005)

Article Pharmacology & Pharmacy

Expression of MRP2 and MDR1 and other hepatic markers in hepatocytes in situ and WRL 68 cells in vitro

D Cizkova et al.

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2005)

Article Pharmacology & Pharmacy

Developmental expression of human hepatic CYP2C9 and CYP2C19

SB Koukouritaki et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)

Article Physiology

Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat

MV St-Pierre et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2004)

Article Biochemistry & Molecular Biology

Identification of phalloidin uptake systems of rat and human liver

F Meier-Abt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2004)

Article Pharmacology & Pharmacy

Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney

JS Warrington et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)

Article Pharmacology & Pharmacy

Developmental expression of the major human hepatic CYP3A enzymes

JC Stevens et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

Article Pharmacology & Pharmacy

Tissue expression, ontogeny, and inducibility of rat organic anion transporting polypeptide 4

N Li et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

Article Pharmacology & Pharmacy

The ontogeny of human drug-metabolizing enzymes: Phase II conjugation enzymes and regulatory mechanisms

DG McCarver et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

Article Gastroenterology & Hepatology

Asynchronous expression and colocalization of Bsep and Mrp2 during development of rat liver

VS Zinchuk et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)

Article Gastroenterology & Hepatology

Developmental regulation of the concentrative nucleoside transporters CNT1 and CNT2 in rat liver

B del Santo et al.

JOURNAL OF HEPATOLOGY (2001)

Article Medicine, General & Internal

Ontogeny of P-glycoprotein in mouse intestine, liver, and kidney

B Mahmood et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2001)

Article Pharmacology & Pharmacy

A comparison of the ontogeny of enterocytic and hepatic cytochromes P450 3A in the rat

TN Johnson et al.

BIOCHEMICAL PHARMACOLOGY (2000)