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IMMUNOLOGICAL REVIEWS (2016)
Protection of host cells by complement regulators
Christoph Q. Schmidt et al.
IMMUNOLOGICAL REVIEWS (2016)
C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend
David Ermert et al.
IMMUNOLOGY LETTERS (2016)
Interim analysis of post-marketing surveillance of eculizumab for paroxysmal nocturnal hemoglobinuria in Japan
Haruhiko Ninomiya et al.
INTERNATIONAL JOURNAL OF HEMATOLOGY (2016)
Polymorphisms in the lectin pathway of complement activation influence the incidence of acute rejection and graft outcome after kidney transplantation
Dela Golshayan et al.
KIDNEY INTERNATIONAL (2016)
A complement-microglial axis drives synapse loss during virus-induced memory impairment
Michael J. Vasek et al.
NATURE (2016)
Schizophrenia risk from complex variation of complement component 4
Aswin Sekar et al.
NATURE (2016)
Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains
Megan C. Rich et al.
NEUROSCIENCE LETTERS (2016)
Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
Andreas Barratt-Due et al.
RHEUMATOLOGY (2016)
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Soyon Hong et al.
SCIENCE (2016)
Complement inhibition in C3 glomerulopathy
Carla M. Nester et al.
SEMINARS IN IMMUNOLOGY (2016)
Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study
Pirow Bekker et al.
PLOS ONE (2016)
MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked
Jozsef Dobo et al.
SCIENTIFIC REPORTS (2016)
Positive impact of eculizumab therapy on surgery for Budd-Chiari syndrome in a patient with paroxysmal nocturnal hemoglobinuria and a long-term history of thrombosis
Silvia De-la-Iglesia et al.
HEMATOLOGY REPORTS (2016)
Complement activation, regulation, and molecular basis for complement-related diseases
Goran Bajic et al.
EMBO JOURNAL (2015)
Devastating recurrent brain ischemic infarctions and retinal disease in pediatric patients with CD59 deficiency
Bruria Ben-Zeev et al.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY (2015)
C5a alters blood-brain barrier integrity in a human invitro model of systemic lupus erythematosus
Supriya D. Mahajan et al.
IMMUNOLOGY (2015)
A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA
Gaurav Mehta et al.
JOURNAL OF IMMUNOLOGY (2015)
Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth
Liam G. Coulthard et al.
JOURNAL OF IMMUNOLOGY (2015)
Soluble Collectin-12 (CL-12) Is a Pattern Recognition Molecule Initiating Complement Activation via the Alternative Pathway
Ying Jie Ma et al.
JOURNAL OF IMMUNOLOGY (2015)
An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy
Eva-Maria Nichols et al.
KIDNEY INTERNATIONAL (2015)
Classical pathway deficiencies - A short analytical review
Lennart Truedsson
MOLECULAR IMMUNOLOGY (2015)
A novel anticonvulsant mechanism via inhibition of complement receptor C5ar1 in murine epilepsy models
Melissa J. Benson et al.
NEUROBIOLOGY OF DISEASE (2015)
Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer
Laure Yatime et al.
NATURE COMMUNICATIONS (2015)
The role of C5a in acute lung injury induced by highly pathogenic viral infections
Renxi Wang et al.
EMERGING MICROBES & INFECTIONS (2015)
Complement in the homeostatic and ischemic brain
Ali Alawieh et al.
FRONTIERS IN IMMUNOLOGY (2015)
Complement system part I - molecular mechanisms of activation and regulation
Nicolas S. Merle et al.
FRONTIERS IN IMMUNOLOGY (2015)
Genetic Variation of COLEC10 and COLEC11 and Association with Serum Levels of Collectin Liver 1 (CL-L1) and Collectin Kidney 1 (CL-K1)
Rafael Bayarri-Olmos et al.
PLOS ONE (2015)
Complement and Its Receptors: New Insights into Human Disease
V. Michael Holers
ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)
Complement 5a Receptor Mediates Angiotensin II-Induced Cardiac Inflammation and Remodeling
Congcong Zhang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
TNT003, an inhibitor of the serine protease C1s, prevents complement activation induced by cold agglutinins
Ju Shi et al.
BLOOD (2014)
Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation
Jing Zhang et al.
FASEB JOURNAL (2014)
Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns
Liliana Schaefer
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Double Blockade of CD14 and Complement C5 Abolishes the Cytokine Storm and Improves Morbidity and Survival in Polymicrobial Sepsis in Mice
Markus Huber-Lang et al.
JOURNAL OF IMMUNOLOGY (2014)
Myeloperoxidase Directs Properdin-Mediated Complement Activation
Joseph O'Flynn et al.
JOURNAL OF INNATE IMMUNITY (2014)
Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood
S. Mantovani et al.
JOURNAL OF NEUROIMMUNOLOGY (2014)
Comprehensive Genetic Analysis of Complement and Coagulation Genes in Atypical Hemolytic Uremic Syndrome
Fengxiao Bu et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2014)
Genetic Variants in C5 and Poor Response to Eculizumab
Jun-ichi Nishimura et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Use of eculizumab and plasma exchange in successful combined liver-kidney transplantation in a case of atypical HUS associated with complement factor H mutation
Ha Tran et al.
PEDIATRIC NEPHROLOGY (2014)
Role for terminal complement activation in amyotrophic lateral sclerosis disease progression
Trent M. Woodruff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
C1q as a unique player in angiogenesis with therapeutic implication in wound healing
Fleur Bossi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
Christoph A. Diebolder et al.
SCIENCE (2014)
C3 Glomerulopathy: The Genetic and Clinical Findings in Dense Deposit Disease and C3 Glomerulonephritis
Xue Xiao et al.
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2014)
A case of paroxysmal nocturnal hemoglobinuria caused by a germline mutation and a somatic mutation in PIGT
Peter M. Krawitz et al.
BLOOD (2013)
Long-term safety and efficacy of sustained eculizumab treatment in patients with paroxysmal nocturnal haemoglobinuria
Peter Hillmen et al.
BRITISH JOURNAL OF HAEMATOLOGY (2013)
Targeting the complement system in systemic lupus erythematosus and other diseases
Maria-Louise Barilla-LaBarca et al.
CLINICAL IMMUNOLOGY (2013)
Complement activation in diseases presenting with thrombotic microangiopathy
Seppo Meri
EUROPEAN JOURNAL OF INTERNAL MEDICINE (2013)
S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3
Helia B. Schonthaler et al.
IMMUNITY (2013)
Primary complement C5 deficiencies - Molecular characterization and clinical review of two families
Lone Schejbel et al.
IMMUNOBIOLOGY (2013)
Long-term efficacy and safety of eculizumab in Japanese patients with PNH: AEGIS trial
Yuzuru Kanakura et al.
INTERNATIONAL JOURNAL OF HEMATOLOGY (2013)
Heteromeric Complexes of Native Collectin Kidney 1 and Collectin Liver 1 Are Found in the Circulation with MASPs and Activate the Complement System
Maiken L. Henriksen et al.
JOURNAL OF IMMUNOLOGY (2013)
Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms
Daniel Ricklin et al.
JOURNAL OF IMMUNOLOGY (2013)
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice
Gareth R. Howell et al.
JOURNAL OF NEUROINFLAMMATION (2013)
Low mannose-binding lectin serum levels are associated with reduced kidney graft survival
Jakob T. Bay et al.
KIDNEY INTERNATIONAL (2013)
Deficiency in Complement Factor B
Charlotte Slade et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic-Uremic Syndrome
C. M. Legendre et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
A systematic review of eculizumab for atypical haemolytic uraemic syndrome (aHUS)
John Rathbone et al.
BMJ OPEN (2013)
Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study
James D. Chalmers et al.
LANCET RESPIRATORY MEDICINE (2013)
Treatment of experimental arthritis by targeting synovial endothelium with a neutralizing recombinant antibody to C5
Paolo Macor et al.
ARTHRITIS AND RHEUMATISM (2012)
Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: Two genes, five proteins and many functions?
Tang Yongqing et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2012)
The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment
Antonio M. Risitano et al.
BLOOD (2012)
Therapeutic targeting of the complement system in age-related macular degeneration: a review
Robyn Troutbeck et al.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2012)
Structure, Function and Control of Complement C5 and its Proteolytic Fragments
N. S. Laursen et al.
CURRENT MOLECULAR MEDICINE (2012)
Monoclonal antibody therapeutics: history and future
Nicholas A. P. S. Buss et al.
CURRENT OPINION IN PHARMACOLOGY (2012)
Damage- and Pathogen-Associated Molecular Patterns and Alarmins: Keys to Sepsis?
S. Denk et al.
EUROPEAN SURGICAL RESEARCH (2012)
Generation of complement component C5a by ischemic neurons promotes neuronal apoptosis
Dale Pavlovski et al.
FASEB JOURNAL (2012)
Regulation of Humoral Immunity by Complement
Michael C. Carroll et al.
IMMUNITY (2012)
H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates
Mateusz Michalski et al.
IMMUNOBIOLOGY (2012)
Bride and groom in systemic inflammation - The bells ring for complement and Toll in cooperation
Andreas Barratt-Due et al.
IMMUNOBIOLOGY (2012)
Interactions of the humoral pattern recognition molecule PTX3 with the complement system
Andrea Doni et al.
IMMUNOBIOLOGY (2012)
Complement and dysbiosis in periodontal disease
George Hajishengallis et al.
IMMUNOBIOLOGY (2012)
Crystal Structure and Functional Characterization of the Complement Regulator Mannose-binding Lectin (MBL)/Ficolin-associated Protein-1 (MAP-1)
Mikkel-Ole Skjoedt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist
Toshiharu Abe et al.
JOURNAL OF IMMUNOLOGY (2012)
Exhaustion of Cytotoxic Effector Systems May Limit Monoclonal Antibody-Based Immunotherapy in Cancer Patients
Frank J. Beurskens et al.
JOURNAL OF IMMUNOLOGY (2012)
C5aR-antagonist significantly reduces the deleterious effect of a blunt chest trauma on fracture healing
Stefan Recknagel et al.
JOURNAL OF ORTHOPAEDIC RESEARCH (2012)
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Dorothy P. Schafer et al.
NEURON (2012)
Mannose-Binding Lectin Deficiency Is Associated with Myocardial Infarction: The HUNT2 Study in Norway
Inga Thorsen Vengen et al.
PLOS ONE (2012)
Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2
David Heja et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The complotype: dictating risk for inflammation and infection
Claire L. Harris et al.
TRENDS IN IMMUNOLOGY (2012)
New insights for C5a and C5a receptors in sepsis
Chunguang Yan et al.
FRONTIERS IN IMMUNOLOGY (2012)
THE COMPLEMENT SYSTEM: HISTORY, PATHWAYS, CASCADE AND INHIBITORS
P. N. Nesargikar et al.
EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY (2012)
Advances in assay of complement function and activation
Morten Harboe et al.
ADVANCED DRUG DELIVERY REVIEWS (2011)
Complement in health and disease
Maria V. Carroll et al.
ADVANCED DRUG DELIVERY REVIEWS (2011)
Disease-Causing Mutations in Genes of the Complement System
Soren E. Degn et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases
Masha Fridkis-Hareli et al.
BLOOD (2011)
Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival
Richard J. Kelly et al.
BLOOD (2011)
Pentraxins (CRP, SAP) in the process of complement activation and clearance of apoptotic bodies through Fcγ receptors
Terry W. Du Clos et al.
CURRENT OPINION IN ORGAN TRANSPLANTATION (2011)
Congenital H-ficolin deficiency in premature infants with severe necrotising enterocolitis
Luregn J. Schlapbach et al.
GUT (2011)
Relationship between Complement Membrane Attack Complex, Chemokine (C-C Motif) Ligand 2 (CCL2) and Vascular Endothelial Growth Factor in Mouse Model of Laser-induced Choroidal Neovascularization
Juan Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway
Daisuke Iwaki et al.
JOURNAL OF IMMUNOLOGY (2011)
Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease
Maria I. Fonseca et al.
JOURNAL OF NEUROINFLAMMATION (2011)
The Pathophysiology of IgA Nephropathy
Hitoshi Suzuki et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2011)
Complement deficiency states and associated infections
Lillemor Skattum et al.
MOLECULAR IMMUNOLOGY (2011)
New Insights of an Old Defense System: Structure, Function, and Clinical Relevance of the Complement System
Christian Ehrnthaller et al.
MOLECULAR MEDICINE (2011)
Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome
Caroline Rooryck et al.
NATURE GENETICS (2011)
Innate and adaptive immunity in amyotrophic lateral sclerosis: Evidence of complement activation
M. Sta et al.
NEUROBIOLOGY OF DISEASE (2011)
Eculizumab in atypical hemolytic uremic syndrome: long-term clinical course and histological findings
Sibylle Tschumi et al.
PEDIATRIC NEPHROLOGY (2011)
MASP1 Mutations in Patients with Facial, Umbilical, Coccygeal, and Auditory Findings of Carnevale, Malpuech, OSA, and Michels Syndromes
Asli Sirmaci et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2010)
Complete functional C1q deficiency associated with systemic lupus erythematosus (SLE)
M. KIRSCHFINK et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)
Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis
D. A. Copland et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)
Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis
Mei Chen et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2010)
A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement Activation
Mikkel-Ole Skjoedt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Double role of mannose-binding lectin in relation to carotid intima-media thickness in patients with rheumatoid arthritis
Lone N. Troelsen et al.
MOLECULAR IMMUNOLOGY (2010)
Complement: a key system for immune surveillance and homeostasis
Daniel Ricklin et al.
NATURE IMMUNOLOGY (2010)
Development trends for human monoclonal antibody therapeutics
Aaron L. Nelson et al.
NATURE REVIEWS DRUG DISCOVERY (2010)
Enhanced synaptic connectivity and epilepsy in C1q knockout mice
Yunxiang Chu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Sterile inflammation: sensing and reacting to damage
Grace Y. Chen et al.
NATURE REVIEWS IMMUNOLOGY (2010)
Long-term efficacy of the complement inhibitor eculizumab in cold agglutinin disease
Alexander Roeth et al.
BLOOD (2009)
Synergistic neuroprotective effects of C3a and C5a receptor blockade following intracerebral hemorrhage
Matthew C. Garrett et al.
BRAIN RESEARCH (2009)
Properdin deficiency associated with recurrent otitis media and pneumonia, and identification of mate carrier with Klinefelter syndrome
Lone Schejbel et al.
CLINICAL IMMUNOLOGY (2009)
Complement component 5a (C5a)
Helga D. Manthey et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)
MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation
Soren E. Degn et al.
JOURNAL OF IMMUNOLOGY (2009)
Mannose-Binding Lectin (MBL) Substitution: Recovery of Opsonic Function In Vivo Lags behind MBL Serum Levels
Nannette Brouwer et al.
JOURNAL OF IMMUNOLOGY (2009)
Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer's Disease
Maria I. Fonseca et al.
JOURNAL OF IMMUNOLOGY (2009)
Expression of complement system components during aging and amyloid deposition in APP transgenic mice
Julia Reichwald et al.
JOURNAL OF NEUROINFLAMMATION (2009)
Eculizumab for paroxysmal nocturnal haemoglobinuria
Charles Parker
LANCET (2009)
Complement in human diseases: Lessons from complement deficiencies
Marina Botto et al.
MOLECULAR IMMUNOLOGY (2009)
Immunodeficiency Associated with FCN3 Mutation and Ficolin-3 Deficiency
Lea Munthe-Fog et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Complement activation and inhibition: a delicate balance
A. P. Sjoberg et al.
TRENDS IN IMMUNOLOGY (2009)
Mannose-binding lectin gene polymorphic variants predispose to the development of bronchopulmonary complications but have no influence on other clinical and laboratory symptoms or signs of common variable immunodeficiency
J. Litzman et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2008)
Diseases associated with the low copy number of the C4B gene encoding C4, the fourth component of complement
A. Szilagyi et al.
CYTOGENETIC AND GENOME RESEARCH (2008)
The alternative complement pathway revisited
Morten Harboe et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)
Complex two-gene modulation of lung disease severity in children with cystic fibrosis
Ruslan Dorfman et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Prevention of experimental autoimmune myasthenia gravis by rat Crry-Ig: A model agent for long-term complement inhibition in vivo
Natalie J. Hepburn et al.
MOLECULAR IMMUNOLOGY (2008)
Dynamic structural changes during complement C3 activation analyzed by hydrogen/deuterium exchange mass spectrometry
Michael C. Schuster et al.
MOLECULAR IMMUNOLOGY (2008)
A role of macrophage complement receptor CRIg in immune clearance and inflammation
Jeannie Q. He et al.
MOLECULAR IMMUNOLOGY (2008)
Structure of and influence of a tick complement inhibitor on human complement component 5
Folmer Fredslund et al.
NATURE IMMUNOLOGY (2008)
Complement component C1q and anti-C1q antibodies in theory and in clinical practice
E. Potlukova et al.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2008)
The pharmacokinetic profile of plasma-derived mannan-binding lectin in healthy adult volunteers and patients with Staphylococcus aureus septicaemia
Peter Bang et al.
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES (2008)
Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria
Robert A. Brodsky et al.
BLOOD (2008)
Successful liver-kidney transplantation in two children with aHUS caused by a mutation in complement factor H
H. Jalanko et al.
AMERICAN JOURNAL OF TRANSPLANTATION (2008)
Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients
Dorthe Hellemann et al.
HUMAN MOLECULAR GENETICS (2007)
The classical complement cascade mediates CNS synapse elimination
Beth Stevens et al.
CELL (2007)
Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation
C. E. Vergunst et al.
RHEUMATOLOGY (2007)
Complement analysis in the 21st century
Tom Eirik Mollnes et al.
MOLECULAR IMMUNOLOGY (2007)
Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models
Irene H. Cheng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis
Kenneth J. Katschke et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Studies on the interactions between C-reactive protein and complement proteins
Adrienn Biro et al.
IMMUNOLOGY (2007)
Hemolytic uremic syndrome:: A factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells
Stefan Heinen et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)
Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): Low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans
Yan Yang et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Activation of the lectin pathway by natural IgM in a model of ischemia/reperfusion injury
Ming Zhang et al.
JOURNAL OF IMMUNOLOGY (2006)
Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation
Iris Leinhase et al.
BMC NEUROSCIENCE (2006)
The role of natural IgM in myocardial ischemia-reperfusion injury
Ming Zhang et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2006)
Therapeutic activity of C5a receptor antagonists in a rat model of neurodegeneration
Trent M. Woodruff et al.
FASEB JOURNAL (2006)
Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D gene in a family with meningococcal infections
Tom Sprong et al.
BLOOD (2006)
Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease
A Roos et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions
M. Harboe et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2006)
Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5
Christa L. Cortesio et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2006)
Clinical aspects and molecular basis of primary deficiencies of complement component C3 and its regulatory proteins factor I and factor H
ES Reis et al.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2006)
Evidence that complement protein C1q interacts with c-reactive protein through its globular head region
Fabian D. G. McGrath et al.
JOURNAL OF IMMUNOLOGY (2006)
Mannose-binding lectin and its genetic variants
P Garred et al.
GENES AND IMMUNITY (2006)
Complement, natural antibodies, autoantibodies and tissue injury
SD Fleming et al.
AUTOIMMUNITY REVIEWS (2006)
Complement deficiency and disease: An update
AG Sjoholm et al.
MOLECULAR IMMUNOLOGY (2006)
Phase I safety, tolerability, and pharmacokinetic study of recombinant human mannan-binding lectin
Kenneth Ahrend Petersen et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2006)
Common variable immunodeficiency and the complement system;: low mannose-binding lectin levels are associated with bronchiectasis
B Fevang et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2005)
C3a expressed in the central nervous system protects against LPS-induced shock
L Boos et al.
NEUROSCIENCE LETTERS (2005)
Binding of complement factor H to endothelial cells is mediated by the carboxy-terminal glycosaminoglycan binding site
TS Jokiranta et al.
AMERICAN JOURNAL OF PATHOLOGY (2005)
Structures of complement component C3 provide insights into the function and evolution of immunity
BJC Janssen et al.
NATURE (2005)
Michels syndrome, Carnevale syndrome, OSA syndrome, and Malpuech syndrome: Variable expression of a single disorder (3MC syndrome)?
L Titomanlio et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2005)
APT070 (Mirococept), a membrane-localised complement inhibitor, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury
DG Souza et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
GS Hageman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Deficiency of somatic hypermutation of the antibody light chain is associated with increased frequency of severe respiratory tract infection in common variable immunodeficiency
P Andersen et al.
BLOOD (2005)
Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA
MA Seelen et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2005)
Complement inhibitor C4b-binding protein -: friend or foe in the innate immune system?
AM Blom et al.
MOLECULAR IMMUNOLOGY (2004)
ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement
D Spitzer et al.
MOLECULAR IMMUNOLOGY (2004)
Differential substrate and inhibitor profiles for human MASP-1 and MASP-2
JS Presanis et al.
MOLECULAR IMMUNOLOGY (2004)
Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus
T Ohlenschlaeger et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation
M Harboe et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2004)
Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein
F Larsen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist
DL Sewell et al.
JOURNAL OF NEUROIMMUNOLOGY (2004)
Impact of mannose-binding lectin on susceptibility to infectious diseases
DP Eisen et al.
CLINICAL INFECTIOUS DISEASES (2003)
The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties
C Gaboriaud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
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BIOCHEMICAL SOCIETY TRANSACTIONS (2003)
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JOURNAL OF IMMUNOLOGY (2003)
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JOURNAL OF NEUROTRAUMA (2001)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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JOURNAL OF CLINICAL INVESTIGATION (2001)
Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models
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JOURNAL OF IMMUNOLOGY (2001)
The C5a complement activation peptide increases IL-1β and IL-6 release from amyloid-β primed human monocytes:: implications for Alzheimer's disease
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