期刊
PHARMACOLOGICAL RESEARCH
卷 164, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2020.105331
关键词
Sestrin2; Regulatory mechanism; Cardiovascular disease; Respiratory disease; Kidney disease
资金
- Qilu Young Scholar's Program of Shandong University [21330089963007]
- National Natural Science Foundation of China [81700329, 81770375]
- Jilin Science and Technology Department [20200801061GH]
This review summarizes the latest research on Sestrin2 in multi-organ stress responses, particularly focusing on its protective role in cardiovascular, respiratory, and renal diseases. It emphasizes the potential therapeutic benefit of targeting Sestrin2 in stress-related diseases, while noting the limited literature on its involvement in heart and vascular diseases, as well as renal and respiratory pathologies.
Sestrin2 (Sesn2) is a powerful anti-oxidant that can prevent acute and chronic diseases. The role of Sesn2 has been thoroughly reviewed in liver, nervous system, and immune system diseases. However, there is a limited number of reviews that have summarized the effects of Sesn2 in heart and vascular diseases, and very less literature-based information is available on involvement of Sesn2 in renal and respiratory pathologies. This review summarizes the latest research on Sesn2 in multi-organ stress responses, with a particular focus on the protective role of Sesn2 in cardiovascular, respiratory, and renal diseases, emphasizing the potential therapeutic benefit of targeting Sesn2 in stress-related diseases.
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