4.5 Article

Modeling Approach to Predict the Impact of Inflammation on the Pharmacokinetics of CYP2C19 and CYP3A4 Substrates

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Summary: The study aimed to investigate voriconazole dose adjustments through PBPK modeling, with the conclusion that prescription of voriconazole should be personalized according to CYP2C19 phenotype, followed by therapeutic drug monitoring of plasma concentrations to guide dose adjustment.

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