期刊
PHARMACEUTICAL CHEMISTRY JOURNAL
卷 54, 期 11, 页码 1140-1144出版社
SPRINGER
DOI: 10.1007/s11094-021-02332-0
关键词
framework amines; analgesic activity
The detailed method for preparing a potential analgesic substance is presented, showcasing its significant analgesic activity in pain conditions.
A method of preparing the potential analgesic substance 4,10-bis((+/-)-5-benzoyl-2,3-dihydro-1H-pyrrolo-[1,2-a]pyrrole-1-carbonyl)-2,6,8,12-tetraacetyl-2,4,6,8,10,12-hexaazatetracyclo[5,5,0(3,11),0(5,9)]dodecane is described in detail. Different conditions for preparing the target substance are considered and its full physicochemical properties are presented. Marked analgesic activity of this innovatory compound was found in conditions of thermal nociception in the hotplate test and acute visceral and somatic deep pain in the acetic writhings test.
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