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The human oral phageome

期刊

PERIODONTOLOGY 2000
卷 86, 期 1, 页码 79-96

出版社

WILEY
DOI: 10.1111/prd.12363

关键词

bacteriophage; dental plaque; microbiome; oral cavity; periodontal disease; phage therapy; phageome

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Oral bacteriophages, especially periodontal ones, are an emerging area of interest with over 2000 known or predicted varieties infecting different bacterial phyla. Research on oral phages is still in its early stages, but their potential impact on oral biofilm ecology and use in phage-based therapy for controlling major periodontal pathogens are both areas of interest.
Oral bacteriophages (or phages), especially periodontal ones, constitute a growing area of interest, but research on oral phages is still in its infancy. Phages are bacterial viruses that may persist as intracellular parasitic deoxyribonucleic acid (DNA) or use bacterial metabolism to replicate and cause bacterial lysis. The microbiomes of saliva, oral mucosa, and dental plaque contain active phage virions, bacterial lysogens (ie, carrying dormant prophages), and bacterial strains containing short fragments of phage DNA. In excess of 2000 oral phages have been confirmed or predicted to infect species of the phyla Actinobacteria (>300 phages), Bacteroidetes (>300 phages), Firmicutes (>1000 phages), Fusobacteria (>200 phages), and Proteobacteria (>700 phages) and three additional phyla (few phages only). This article assesses the current knowledge of the diversity of the oral phage population and the mechanisms by which phages may impact the ecology of oral biofilms. The potential use of phage-based therapy to control major periodontal pathogens is also discussed.

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