期刊
PEDIATRIC ALLERGY AND IMMUNOLOGY
卷 32, 期 5, 页码 859-871出版社
WILEY
DOI: 10.1111/pai.13462
关键词
allergic sensitization; atopic sensitization; cohort study; food allergy; open food challenge; parental animal allergy; parental asthma; parental atopic diseases; parental atopic eczema; parental food allergy; parental pollen allergy; population-based evidence; sensitization to animals; sensitization to food; sensitization to pollen; sIgE; skin prick test
资金
- Finnish Cultural Foundation, South Karelia Regional Fund (Lauri and Lahja Hotinen Fund)
- Northern Ostrobothnia hospital district
- Finnish Medical Association
- Viipuri Tuberculosis Foundation
- Allergy Foundation
- Finnish Cultural Foundation, South Karelia Regional fund
- Medical Society of South Karelia
- Finnish Cultural Foundation (Pekka and Jukka-Pekka Lylykari's Fund)
- Social Insurance Institution of Finland
- Alma and K.A. Snellman Foundation
- Tyyni Tani Foundation
- Lappeenranta City Council
- Kymenlaakson Terveyden Turva ry
- Finnish Pediatric Research Foundation
- Vaino and Laina Kivi Foundation
- hospital district of South Karelia
Parental atopic diseases are associated with offspring's atopic sensitization and food allergies, especially in male offspring. A pronounced association was found between parental pollen allergy and male offspring's pollen sensitization.
Background In genetic studies and selected study populations, parental atopy has been associated with atopic diseases in offspring. Our aim was to identify the association between parental atopic diseases and the offspring's atopic sensitization and food allergies, and their effect modifications due to the offspring's sex. Methods The study population (N = 5564) (born between 2001 and 2006) was identified from the population register and live in the province of South Karelia, Finland. Questionnaire-based information on parental atopic diseases was available for 3592 children. The results of skin prick tests, specific IgE tests, and open food challenges (OFC) were collected from patient records. Results By 12 years of age, the cumulative incidence of sensitization to food (14% vs 7%, hazard ratio 2.13; 95% CI 1.68-2.69), animal (10% vs 6%, 1.86; 1.42-2.44), and pollen allergens (12% vs 6%, 2.43; 1.85-3.19), as well as food allergies (positive OFC, 5% vs 2%, 2.28; 1.57-3.33), was higher in the offspring of parents with atopic diseases. The cumulative incidence for pollen sensitization was twofold higher for the female offspring of parents with atopic diseases than those of parents without, while it was almost threefold higher among males. The association between parental pollen allergy and the offspring's pollen sensitization was modified by sex according to additive scale estimates (RERI 1.03; 95% CI 0.13-1.91). Conclusion Until adolescence, parental atopic diseases have a relatively strong association with the offspring's, particularly male offspring's, atopic sensitization, and food allergies. A pronounced association was found between parental pollen allergy and the male offspring's pollen sensitization.
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