期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 219, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.prp.2021.153346
关键词
Esophageal squamous cell carcinoma; Head and neck squamous cell carcinoma; HPV; p53; CD4
类别
资金
- Italian Ministry of Health
The study suggests that HPV infection is not a factor associated with esophageal squamous cell carcinoma (ESCC) after head and neck squamous cell carcinoma (HNSCC). Instead, p53 overexpression is common in HNSCC-associated ESCCs. The altered immune microenvironment, characterized by dysregulated lymphomonocytic infiltration, may play a crucial role in the development of metachronous ESCC.
Background: In some HNSCC patients, a metachronous ESCC may develop. No information is available on the HNSCC-associated ESCCs microenvironment and etiology. Methods: Among 134 ESCCs surgically treated between 2009 and 2015, a series of 6 HNSCC-associated ESCCs was collected. A series of 12 sex-, age-and stage-matched ESCCs with no previous oncological medical history was selected for comparison. Histologic assessment of intratumoral inflammatory infiltration and immunohistochemistry for CD4, CD8, CD80, PD1, PD-L1 and p53 were performed. HPV detection/genotyping was assessed by PCR single step and reverse line blot. Results: HPV DNA was negative in all the HNSCC-associated ESCCs. In comparison to non-HNSCC-associated carcinomas, the 6 cases presented a lower lymphomonocytic infiltration, which also corresponded to a lower prevalence of CD4 + T cell infiltration and, 5/6 cases presented a PD-L1 CPS > 1. All the HNSCC-associated ESCCs resulted positive for p53 immunostaining in >50 % of cancer cells. Conclusion: Our study suggests that HPV infection is not an etiological factor associated to ESCC after HNSCC. On the other hand, p53 overexpression is a common finding. Moreover, our data suggest that an altered immune microenvironment, conditioned by a dysregulation in lymphomonocytic infiltration, may be a crucial factor allowing the occurrence of a metachronous ESCC.
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